Results 61 to 70 of about 28,691 (244)

Fast and reliable identification of axons, axon initial segments and dendrites with local field potential recording

Frontiers in Cellular Neuroscience, 2015
The axon initial segment (AIS) is an essential neuronal compartment. It is usually where action potentials are initiated. Recent studies demonstrated that the AIS is a plastic structure that can be regulated by neuronal activity and by the activation of ...
Anders Victor ePetersen, Emil Østergård Johansen, Jean-François ePerrier   +2 more
doaj   +1 more source

Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds

Advanced Functional Materials, EarlyView.
This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley   +1 more source

Modulation of axon excitable domains by astrocytes and microglia

Frontiers in Cellular Neuroscience
Neuronal communication depends on neuronal polarity and the integrity of axonal excitable domains, including the axon initial segment (AIS), nodes of Ranvier, and presynaptic terminals. In addition to the influence of neuronal input on their function and
Juan José Garrido, Juan José Garrido
doaj   +1 more source

Differential Trafficking of Transport Vesicles Contributes to the Localization of Dendritic Proteins

Cell Reports, 2012
In neurons, transmembrane proteins are targeted to dendrites in vesicles that traffic solely within the somatodendritic compartment. How these vesicles are retained within the somatodendritic domain is unknown.
Sarmad Al-Bassam, Min Xu, Thomas J. Wandless, Don B. Arnold   +3 more
doaj   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment

Cell Reports, 2017
Neuronal chloride levels are developmentally regulated. Early in life, high intracellular concentrations support chloride efflux and depolarization at GABAergic synapses.
Gina Rinetti-Vargas, Khanhky Phamluong, Dorit Ron, Kevin J. Bender   +3 more
doaj   +1 more source

TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment [PDF]

The Journal of Neuroscience, 2019
Selective cargo transport into axons and dendrites over the microtubule network is essential for neuron polarization. The axon initial segment (AIS) separates the axon from the somatodendritic compartment and controls the microtubule-dependent transport into the axon.
Martin Harterink, Karin Vocking, Xingxiu Pan, Eva M. Soriano Jerez, Lotte Slenders, Amélie Fréal, Roderick P. Tas, Willine J. van de Wetering, Karina Timmer, Jasmijn Motshagen, Sam F.B. van Beuningen, Lukas C. Kapitein, Willie J.C. Geerts, Jan A. Post, Casper C. Hoogenraad   +14 more
openaire   +4 more sources

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

Advanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco, Roberto Baretta, Andrea Di Fonzo, Andrea Armirotti, Stefano Cinti, Mara Mirasoli, Marco Frasconi, Claudia Corbo   +7 more
wiley   +1 more source

Amyloid-β plaques disrupt axon initial segments [PDF]

Experimental Neurology, 2016
Amyloid-β (Aβ) plaques are one of the central pathologies of Alzheimer's disease (AD). Plaque formation in animal models of AD coincides with the appearance of synaptic abnormalities, aberrant neuronal excitability, and cognitive decline. Aβ plaques may disrupt neuronal excitability since they have been proposed to be synaptotoxic, to induce axonal ...
Miguel A, Marin, Jokubus, Ziburkus, Joanna, Jankowsky, Matthew N, Rasband   +3 more
openaire   +2 more sources

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source