Results 81 to 90 of about 29,685 (270)

Casein kinase 2 and microtubules control axon initial segment formation

, 2012
The axon initial segment (AIS) is a unique axonal subdomain responsible for the generation of the neuronal action potential and the maintenance of the axon-dendritic functional polarity.
Sánchez-Ponce, Diana, Garrido Jurado, Juan José, Muñoz Céspedes, Alberto   +2 more
core   +1 more source

Amyloid-β plaques disrupt axon initial segments [PDF]

Experimental Neurology, 2016
Amyloid-β (Aβ) plaques are one of the central pathologies of Alzheimer's disease (AD). Plaque formation in animal models of AD coincides with the appearance of synaptic abnormalities, aberrant neuronal excitability, and cognitive decline. Aβ plaques may disrupt neuronal excitability since they have been proposed to be synaptotoxic, to induce axonal ...
Miguel A, Marin, Jokubus, Ziburkus, Joanna, Jankowsky, Matthew N, Rasband   +3 more
openaire   +2 more sources

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

The axon initial segment drives the neuron’s extracellular action potential

, 2018
Extracellular voltage fields produced by a neuron’s action potentials provide a primary means for studying neuron function, yet their biophysical sources remain ambiguous.
Douglas J. Bakkum, Urs Frey, David Jaeckel, Hirokazu Takahashi, Andreas Hierlemann, Milos Radivojevic, Marie Engelene J. Obien   +6 more
core   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

Advanced Science
The axon initial segment (AIS), serving as the site for initiating action potentials (APs), is a key target for efficient regulation of neuronal activity.
Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai   +7 more
doaj   +1 more source

Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment

Cell Reports, 2017
Neuronal chloride levels are developmentally regulated. Early in life, high intracellular concentrations support chloride efflux and depolarization at GABAergic synapses.
Gina Rinetti-Vargas, Khanhky Phamluong, Dorit Ron, Kevin J. Bender   +3 more
doaj   +1 more source

Bias‐Field Free Single‐Frequency CW‐ODMR of Nitrogen‐Vacancy Centers in Diamond for the Detection of Transient Electrical Signals

Advanced Materials Interfaces, EarlyView.
Simplified quantum sensing technique for the detection of short electrical signals occurring in neuronal signaling or bioinspired technologies. We demonstrate a single frequency continuous‐wave optically detected magnetic resonance (CW‐ODMR) approach to sense signals that can be as short as 0.2 ms.
João Paulo Silva, Orlando D. Cunha, Pedro Magalhães, Filipe Camarneiro, Jana B. Nieder   +4 more
wiley   +1 more source

Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment

, 2017
International audienceThe axon initial segment (AIS) is a highly specialized neuronal compartment that plays a key role in neuronal development and excitability. It concentrates multiple membrane proteins such as ion channels and cell adhesion molecules (
Montersino, Audrey, Nadine Clerc, Rueda-Boroni, Fanny, Dargent, Bénédicte, Bénédicte Dargent, Audrey Montersino, Leterrier, Christophe, Francis Castets, Fanny Rueda-Boroni, Clerc, Nadine, Christophe Leterrier, Castets, Francis   +11 more
core   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

In vivo assembly of the axon initial segment in motor neurons [PDF]

Brain Structure and Function, 2013
The axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood. Our study in single electroporated motor neurons in mouse embryos revealed that AnkyrinG (AnkG), the AIS master organizer, is ...
Le Bras, Barbara, Freal, Amelie, Czarnecki, Antonny, Legendre, Pascal, Bullier, Erika, Komada, Masayuki, Brophy, Peter J., Davenne, Marc, Couraud, Francois   +8 more
openaire   +3 more sources