Results 51 to 60 of about 913,012 (252)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Sofcomputing approach to melody generation based on harmonic analysis [PDF]
International Journal of Electronics and TelecommunicationsThis work aims to create an ANN-based system for a musical improviser. An artificial improviser of "hearing" music will create a melody. The data supplied to the improviser is MIDItype musical data.
Jarosław Mazurkiewicz
doaj +3 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Performance of conceptual and black-box models in flood warning systems
Cogent Engineering, 2016 Flood forecasting is a core of flood forecasting and flood warning system which can be implemented by both conceptual rainfall–runoff (CRR) model and black-box rainfall–runoff (BBRR) model.
Mohammad Ebrahim Banihabib
doaj +1 more source
The Journal of Engineering, 2019 This study presents a method to predict a day-ahead solar irradiation curve, under extreme meteorological phenomena (Föhn, north and south winds), existing in the province of San Juan, Argentina.
Luis Carlos Parra Raffán +2 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
, 1927 Ann Henderson nee Cox emigrated to South Australia from England with her first husband, John George Kelsey, and eight of her ten children, in 1860. They came to the Territory in 1873 where Ann ran businesses with her husband including the Palmerston Club
Henderson, Ann
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Original letters from the CCHS Manuscripts Collection, MS #8652, courtesy of Chester County Historical Society, West Chester, PA. Ann Preston was a member of the first graduating class of the Woman's Medical College of Pennsylvania in 1852.
Preston, Ann, 1813-1872
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source