Results 71 to 80 of about 913,012 (252)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Ann Preston was a member of the first graduating class of the Woman's Medical College of Pennsylvania in 1852.
Preston, Ann, 1813-1872
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Applying Artificial Neural Networks and Multiple Linear Regression models to estimate Forest density in Marivan forests [PDF]
مجله جنگل ایران, 2016 Studying and modeling quantitative characteristics of forest to develop and direct the ecosystem toward optimal aims and conservative activities is considered as an eminent operation.
sasan vafaei +3 more
doaj
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Machine learning algorithm for improving performance on 3 AQ-screening classification
Communications in Science and Technology, 2019 Autism Spectrum Disorder (ASD) classification using machine learning can help parents, caregivers, psychiatrists, and patients to obtain the results of early detection of ASD.
Taftazani Ghazi Pratama +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Artificial neural network-based modeling of surface roughness in machining of Multiwall Carbon Nanotube reinforced polymer (epoxy) nanocomposites [PDF]
FME Transactions, 2020 In the manufacturing process, the surface roughness acts as one of the vital response to define the machined product quality.This manuscript platforms on the modeling of surface roughness(Ra) during milling of Multiwall Carbon Nanotube (MWCNT) reinforced
Kharwar Prakhar Kumar +1 more
doaj