Results 31 to 40 of about 1,612,255 (303)

Les Cahiers Anne Hébert. 16, Archives et écritures de femmes : Louise Dupré et Hélène Monette [PDF]

, 2019
"Ce numéro 16 des "Cahiers Anne Hébert" ouvre ses pages à l’étude de l’œuvre de deux écrivaines québécoises, Louise Dupré et Hélène Monette, dont le Centre Anne-Hébert et le Service des archives de l’Université de Sherbrooke ont acquis ...

core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Anne Babalar ve Öğretmenlerin Bakış Açısıyla Erken Çocukluk Döneminde Değerler Eğitimi

Değerler Eğitimi Dergisi
Nitel yöntemlerden fenomolojik araştırma deseninin kullanıldığı bu araştırmada öğretmenlerin, anne ve babaların erken çocukluk döneminde değerler eğitimine ilişkin görüşlerinin incelenme-si amaçlanmıştır.
Sümeyya Tatlı Harmancı
doaj   +1 more source

ANNE DAVRANIŞ ÖLÇEĞİ VE ANNE-ERGEN İLİŞKİ NİTELİĞİ ÖLÇEĞİ: ERGEN VE ANNE FORMLARININ PSİKOMETRİK ÖZELLİKLERİNİN SINANMASI

Nesne Psikoloji Dergisi, 2022
Bu çalışmada anne babanın çocuğa yönelik davranışlarını ölçmek amacıyla geliştirilmiş olan Ebeveyn Davranış Ölçeği ve anne baba-çocuk arasındaki karşılıklı ilişkilerin niteliğini ölçmek amacıyla geliştirilmiş olan Ebeveyn-Ergen İlişki Niteliği Ölçeği ...
Ayşen Güre, Aysun Ergül Topçu
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Difficulties Experienced by Mothers in Newly Diagnosed Type 1 Diabetes Mellitus: A Phenomenological Study

Journal of Nursology
Objective: The aim of this study was to explore the experiences of mothers of newly diagnosed Type 1 Diabetes Mellitus (T1DM) children, to identify the difficulties mothers face in diabetes care, and to identify appropriate solutions.Methods: Mothers of ...
Semra Çetinkaya, Nurdan Yildirim, Nebahat Bora Güneş, Melike Taşdelen Baş   +3 more
doaj   +1 more source

Annelerin İnfantil Kolik İçin Kullandıkları Uygulamalar ve Yararları Konusundaki Algıları [tr] / The Practices Used by Mothers to Infantile Colic and Their Perceptions on the Benefits of The Practices [en]

Online Türk Sağlık Bilimleri Dergisi, 2020
Amaç: Bu araştırma infantil koliği olan bebeklerin annelerinin koliği azaltmaya yönelik yaptığı uygulamaları ve yararları hakkındaki algılarını belirlemek amacıyla yapılmıştır.
Birsen MUTLU, Zeynep ERKUT, Şerife AVCI, Sıdıka Sümeyye GİRGİN, İsmail GÖNEN   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source