Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Tolkien in the New Century: Essays in Honor of Tom Shippey (2014), edited by John Wm. Houghton, Janet Brennan Croft, Nancy Martsch, John D. Rateliff, and Robin Anne Reid [PDF]
Book review by Gergely Nagy of Tolkien in the New Century: Essays in Honor of Tom Shippey (2014), edited by John Wm. Houghton, Janet Brennan Croft, Nancy Martsch, John D.
Nagy, Gergely
core +2 more sources
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
ZİHİNSEL ENGELLİ ÇOCUĞU OLAN ANNELERİN ÖLÜM KAYGISI İLE SOSYAL POLİTİKALARA GÜVEN İLİŞKİSİ
Sosyalpolitikalar dezavantajlı gruplara fayda sağlamak amacıyla oluşturulmaktadır. Ancakbazı durumlarda bu politikalara duyulan güven düzeyinin düşük olması bir takım olumsuzsonuçlar doğurabilmektedir.
Recep Yıldız, Merve Nur Oktar
doaj +1 more source
Monitoring of stimulated cycles in assisted reproduction (IVF and ICSI) [PDF]
Acknowledgements: We are grateful to Marian Showell for her help in updating the search strategy and carrying out the literature search; to Anne Lethaby for translating the Spanish paper and extracting data; and in particular to Helen Nagels and Jane ...
Bhattacharya, Siladitya +3 more
core +3 more sources
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem +17 more
wiley +1 more source
ANNELERİN EMZİRMEYE YÖNELİK SOSYAL MEDYA KULLANIM DURUMLARI
Amaç:Bu çalışmanın amacı; emzirme ile ilgili sosyal medyadan alınan desteğinkullanım nedenlerini ve emzirme üzerindeki sonuçlarını belirlemektir.Yöntem: Tanımlayıcı türdeki araştırmanın evrenini,Emzirme Sanatı/Emzirme Sorun ve Çözümleri Facebook ...
Sevgi Özsoy, Tuğba Dündar
doaj
‘You cannot show me’: Two Tudor Coronation Processions, Shakespeare’s King Henry VIII and the Staging of Anne Boleyn [PDF]
In this paper, Leahy argues that Shakespeare’s portrayal of Anne Boleyn in King Henry VIII has traditionally been regarded as one that does not take account of her ambiguous historical position, and he goes on to examine this portrayal in the light of
Leahy, WJ
core
Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran +13 more
wiley +1 more source

