Results 201 to 210 of about 747,925 (322)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A full-automated tumor budding annotation approach in hematoxylin and eosin-stained whole slide images of colorectal cancer. [PDF]

NPJ Precis Oncol
Peng S, Chang X, Luo Y, Tang H, Yang M, Zhong C, Deng C, Hao S, Jin Y, Li M, Bai X, Nie X.   +11 more
europepmc   +1 more source

S12 Table - scTrans: Sparse attention powers fast and accurate cell type annotation in single-cell RNA-seq data

Zhiyi Zou (14674007), Ying Liu (18461), Yuting Bai (3428096), Jiawei Luo (763133), Zhaolei Zhang (772)   +4 more
openalex   +1 more source

Automated LC-HRMS(/MS) Approach for the Annotation of Fragment Ions Derived from Stable Isotope Labeling-Assisted Untargeted Metabolomics

, 2014
Nora K. N. Neumann, Sylvia Lehner, Bernhard Kluger, Christoph Bueschl, Karoline Sedelmaier, Marc Lemmens, Rudolf Krska, Rainer Schuhmacher   +7 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

scANMF: Prior Knowledge and Graph-Regularized NMF for Accurate Cell Type Annotation in scRNA-seq. [PDF]

Int J Mol Sci
Chi W, Zheng Y, Fang H, Shi S.
europepmc   +1 more source

RAST Annotation corresponding to aromatic compound metabolism.

Thasneema Rafic (22647847), Mohammed Alarawi (11464239), Omer Salem Alkhnbashi (22647850), Assad Al-Thukair (22647853), Ajibola H. Okeyode (22647856), Karthikeyan G (15312895), Alexis Nzila (181169)   +6 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The plant transcriptome – from integrating observations to models

Frontiers in Plant Science, 2013
Alisdair eFernie, Bjoern eUsadel
doaj   +1 more source

Comparing Interactive Machine Learning and Unassisted Segmentation of Geographic Atrophy From Fundus Autofluorescence. [PDF]

Transl Vis Sci Technol
Bearce B, McNamara S, Kinder S, Manoharan N, Lisker A, Arguinchona L, Marks B, Roseto I, Barrientos L, Milner D, Gnanaraj R, Gill Z, Tukel M, Abe-Ridgway K, Mandava N, Singh P, Nebbia G, Kalpathy-Cramer J.   +17 more
europepmc   +1 more source