Results 121 to 130 of about 641,605 (256)
The Japanese Catheter Ablation Registry (J-AB): Annual Report in 2023. [PDF]
J ArrhythmKusano K, Inoue K, Kanaoka K, Miyamoto K, Okumura Y, Iwasaki YK, Satomi K, Takatsuki S, Nakamura K, Yamashita S, Masuda M, Iwanaga Y, Chishaki-Kawabata S, Yamane T, Shimizu W, Tada H, J‐AB registry investigators. +16 moreeuropepmc +1 more sourceThe role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti +11 morewiley +1 more sourceThoracic and cardiovascular surgeries in Japan during 2024 : Annual report by the Japanese Association for Thoracic Surgery. [PDF]
Gen Thorac Cardiovasc SurgCommittee for Scientific Affairs, The Japanese Association for Thoracic Surgery, Yoshimura N, Sato Y, Takeuchi H, Abe T, Doi T, Yoshikawa TF, Hirata Y, Ishida M, Iwata H, Kamei T, Kawaharada N, Kawamoto S, Kohno K, Koyanagi K, Kumamaru H, Matsumiya G, Minatoya K, Motomura N, Nakahara R, Okada M, Saji H, Saito A, Suzuki K, Takemura H, Kimura Y, Tatsuishi W, Yamamoto H, Shiose A, Yasuda T, Chida M, Shimizu H. +32 moreeuropepmc +1 more sourceEngineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceKeratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer +13 morewiley +1 more sourceThe ERA Registry Annual Report 2023: epidemiology of kidney replacement therapy in Europe, with a focus on age comparisons. [PDF]
Clin Kidney JHoekstra MWF, Boenink R, Bonthuis M, Boerstra BA, Astley ME, Montez de Sousa IR, Gjorgjievski N, Resic H, Mitsides N, Hommel K, Guidotti R, Marín Sánchez I, Slon-Roblero MF, Artamendi M, Beckerman P, Buchwinkler L, Gellert R, Kuzema V, Okša A, Comas J, Heylen LMTJ, Lassalle M, Hernandez Ramirez S, Santhakumaran S, Seyahi N, Åsberg A, Weekers LE, Muñoz-Terol JM, Trujillo-Alemán S, Memeti Smaili F, Ots-Rosenberg M, Indridason OS, Komissarov KS, Ten Dam MAGJ, Stendahl M, Galvão AA, Ortiz A, Stel VS, Kramer A. +38 moreeuropepmc +1 more sourceEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceMinimally invasive cardiac surgeries in 2022: annual report by Japanese Society of Minimally Invasive Cardiac Surgery. [PDF]
Gen Thorac Cardiovasc SurgShimokawa T, Kumamaru H, Motomura N, Nishi H, Nakajima H, Kamiya H, Okamoto K, Hosoba S, Saiki Y, Miura T, Tabata M, Shiose A, Sakaguchi T. +12 moreeuropepmc +1 more source