Results 111 to 120 of about 3,722,939 (253)

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Enhancing Daylight and Energy Efficiency in Hot Climate Regions with a Perforated Shading System Using a Hybrid Approach Considering Different Case Studies

Buildings
Direct sunlight causes glare and reduces indoor daylight quality, making shading systems essential. This study proposes and validates a perforated shading screen (PSS) to enhance daylighting and energy efficiency. A hybrid approach integrating parametric
Basma Gaber, Changhong Zhan, Xueying Han, Mohamed Omar, Guanghao Li   +4 more
doaj   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

Optimizing Window-to-Floor Ratio and Glazing for Daylight and Cooling in Tropical Educational Buildings: A Case Study in Chiang Mai, Thailand

Journal of Daylighting
In tropical climates, where cooling loads dominate building energy use, minimizing cooling demand is particularly critical for achieving carbon neutrality in educational buildings while maintaining adequate daylight and visual comfort.
Ting Way Lim, Yuttana Tongtuam, Nawit Ongsavangchai   +2 more
doaj   +1 more source

Understanding and Regulating C–N Coupling Pathways for Electrocatalytic Urea Synthesis From CO2 and NO3−/NO2−

Advanced Science, EarlyView.
Understanding and regulating C–N coupling is central to electrocatalytic urea synthesis from CO2 and NO3−/NO2−. This review outlines representative coupling pathways, summarizes carbon‐ and nitrogen‐side intermediate regulation strategies, and highlights in situ/operando tools for mechanistic clarification and catalyst design. ABSTRACT Electrocatalytic
Xingbao Chen, Zhuo Li, Lebin Cai, Paul Kilmartin, Bao Yu Xia, Ziyun Wang   +5 more
wiley   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Building information modeling – simulation and analysis of a University Edifice and its environs – A sustainable design approach

Green Technologies and Sustainability
This study utilized Building Information Modeling (BIM) to refine an existing campus master plan, improving the built environment concerning usability and sustainability.
G.T.N. Veerendra, Subhashish Dey, Emma Jane Mantle, A.V. Phani Manoj, Siva Shanmukha Anjaneya Babu Padavala   +4 more
doaj   +1 more source

Epigenetic Reactivation of TNFRSF19 Suppresses Mitophagy and Sensitizes Triple‐Negative Breast Cancer to Doxorubicin

Advanced Science, EarlyView.
TNFRSF19 is an epigenetically silenced regulator of mitophagy in triple‐negative breast cancer. TNFRSF19 deficiency activates the TGFBR1–SMAD3–PINK1 axis to promote mitophagy and confer doxorubicin resistance, whereas decitabine‐mediated restoration of TNFRSF19 suppresses mitophagy and enhances doxorubicin sensitivity, revealing a targetable epigenetic–
Shiyang Liu, Chenguang Liu, Weihong Zheng, Xiaofei Tong, Zhengwei Gui, Zonghong Lu, Sun Ieong, Lin Zhang   +7 more
wiley   +1 more source

Performance improvement of vertically installed bifacial solar panels with adjustable reflectors optimized using the Taguchi method

Energy Nexus
The global deployment of bifacial photovoltaic (PV) modules has accelerated due to their ability to capture both direct and reflected sunlight, offering higher energy yields than traditional monofacial panels.
Hao-Pei Yan, Ting-Wei Liao, Chien-Chun Hsieh, Chao-Yang Huang, Rei-Cheng Juang, Chung-Feng Jeffrey Kuo   +5 more
doaj   +1 more source

Impact of climate change on sky conditions over nearly three decades in a tropical urban environment: A simulation analysis for daylight performance in Makassar City

Results in Engineering
This study evaluates climate change impacts on daylight availability in Makassar, Indonesia, through integrated analysis of meteorological data (1995–2023) and daylight performance simulations across multiple building configurations.
Atikah Nurulfajri Baharuddin, Baharuddin Hamzah, Nurul Jamala, Rizki A. Mangkuto   +3 more
doaj   +1 more source