Results 81 to 90 of about 23,791 (265)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Performance of a two-body wave energy converter with an annular heave plate

Flow
We theoretically examine the performance of a two-body wave energy converter (WEC) featuring a floating sphere and a submerged annular heave plate, connected by a power take-off (PTO) system. Utilising linear wave theory, we derive the system’s frequency-
Raj Tamakuwala, Muhammad Usman, Nathan Tom, Hassan Masoud   +3 more
doaj   +1 more source

Peripapillary perfused capillary density in true versus pseudoexfoliation syndrome: An OCTA study.

PLoS ONE, 2020
PurposeTo compare peripapillary perfused capillary density (PCD) among eyes with true exfoliation syndrome (TEX), eyes with pseudoexfoliation syndrome (PEX), and healthy control eyes.Materials and methodsIn this observational cross-sectional study, eyes ...
Phantaraporn Tangtammaruk, Purit Petpiroon, Wasu Supakonatanasan, Chaiwat Teekhasaenee, Yanin Suwan   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Positive Radial Solutions for Semilinear Biharmonic Equations in Annular Domains

Revista Matemática Complutense, 1993
Summary: We study the existence of positive radial solutions of \(\Delta^ 2u= g(| x|) f(u)\) in an annulus with Dirichlet boundary conditions. We establish that the equation has at least one positive radially symmetric solution on any annulus if \(f\) and \(g\) are nonnegative, \(g\not\equiv 0\) and \(f\) is superlinear at zero and \(+\infty\). We also
openaire   +3 more sources

Modeling and Performance Analysis of Shielded Differential Annular Through-Silicon Via (SD-ATSV) for 3-D ICs

IEEE Access, 2018
A shielded-differential annular through-silicon via (SD-ATSV) is proposed and investigated. The equivalent circuit model is developed with the influence of the electrically floating silicon substrate taken into account.
Kai Fu, Wen-Sheng Zhao, Gaofeng Wang, Madhavan Swaminathan   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Physics-Informed Neural Networks for Solving 2D Frequency-Domain Electromagnetic Waves in the Differential Form of Maxwell’s Equations

Advances in Mathematical Physics
This article investigates the application of physics-informed neural networks (PINNs) for solving two-dimensional (2D) frequency-domain Maxwell’s equations in complex geometries, including rectangular, circular, annular, and eccentric circular domains ...
Abdenie Tukie Tufa, Tamirat Temesgen Dufera, Mitiku Daba Firdi, Alemayehu Tamirie Deresse   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source