Results 91 to 100 of about 46,800 (289)

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

Advanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta, Mette Galsgaard Malle, Emily Tsang, Marjan Omer, Mads K. Skaanning, Sarah Youssef, Jørgen Kjems, Kurt V. Gothelf   +7 more
wiley   +1 more source

The transition zone as a host for recycled volatiles: Evidence from nitrogen and carbon isotopes in ultra-deep diamonds from Monastery and Jagersfontein (South Africa) [PDF]

, 2017
Sublithospheric (ultra-deep) diamonds provide a unique window into the deepest parts of Earth's mantle, which otherwise remain inaccessible. Here, we report the first combined C- and N-isotopic data for diamonds from the Monastery and Jagersfontein ...
Gurney, J.J., Harris, J.W., Le Pioufle, A., Palot, M., Pearson, D.G., Stachel, T., Stern, R.A.   +6 more
core   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

PHARMACOKINETIC EVALUATION OF CLARITHROMYCIN ORAL CONTROLLED RELEASE MATRIX TABLETS FOR DESIRED BIOAVAILABILITY AND IMPROVED PATIENT COMPLIANCE

Gomal Journal of Medical Sciences, 2016
Background: Controlled release drug delivery systems release drug at controlled rate over desired period of time. It helps to maintain constant drug concentration in plasma and improves the patient compliance.
Muhammad Ramzan
doaj  

Decoding Trap States in Working 2D Perovskite Multi‐Functional Devices

Advanced Science, EarlyView.
Illustration of the photoluminescence spectrum and energy‐level landscape governing trap‐mediated carrier dynamics in 2D F‐PEAI photodetectors. A novel approach capturing dynamic trap occupation and retrapping in devices under operating conditions, directly links defect energetics to carrier transport and enhanced photoresponse in multifunctional ...
Ioannis Leontis, Karl Jonas Riisnaes, Hoi Tung Lam, Rosanna Mastria, Luisa De Marco, Annalisa Coriolano, Steven Hepplestone, Monica Felicia Craciun, Saverio Russo   +8 more
wiley   +1 more source

A DNA Tetrahedron Delivery Asiatic Acid to Reprogram Mitochondrial Metabolism for Promoting Bone Regeneration via STAT3 Phosphorylation

Advanced Science, EarlyView.
A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang, Yiming Zhang, Yisheng Feng, Qixiang Yang, Beiyuan Gao, Haiyang Xu, Cheng Huang, Kaili Lin, Yuanzhi Xu, Peiqi Zhu   +9 more
wiley   +1 more source

Radiocarbon dating of Quaternary groundwater in the North China Plain and its implication to 14C correction

Shuiwen dizhi gongcheng dizhi
14C is commonly used in groundwater dating. Due to the uncertainty of the initial 14C contents (A0) and the complex geochemical processes in the subsurface, the 14C ages were corrected but remain largely uncertain.
Jie LI, Yuxi XIE, Lijun TIAN, Yifei XING, Yulian LIU, Xuan JIAO, Shuchen FEI   +6 more
doaj   +1 more source

New insights in the origin and evolution of the old, metal-rich open cluster NGC 6791

, 2017
NGC 6791 is one of the most studied open clusters, it is massive ($\sim5000\,M_{\odot}$), located at the solar circle, old ($~8\,$Gyr) and yet the most metal-rich cluster (${\rm [Fe/H]}\simeq0.4$) known in the Milky Way. By performing an orbital analysis
Gieles, Mark, Martinez-Medina, Luis A., Peimbert, Antonio, Pichardo, Barbara   +3 more
core   +1 more source

Room‐Temperature Alane Dehydrogenation for Visible‐Light‐Driven Photocatalytic Hydrogen Supply System

Advanced Science, EarlyView.
In situ formed Al/MOF enables viable visible‐light‐driven photocatalytic dehydrogenation of alane (AlH3) confirming practical application. Results demonstrate that Al nanoparticles prolong lifetime of photogenerated charge carriers via localized surface plasmon resonance induced hot electron injection, while AlH3 chemisorption triggers interfacial ...
Ting‐Ting Li, Li‐Cheng Liang, Rui‐Qi Chen, Chun‐Qi Zhang, Sheng‐Nan Zhang, Wen‐Wen Cheng, Xi‐Hao Chen, Ning Wang, Juan‐Ding Xiao, Qing‐Qing Yang, Fei Liang, Chao‐Feng Zhang   +11 more
wiley   +1 more source

Formulation of gastroresistant tablets containing sodium alendronate-loaded blend microparticles

Brazilian Journal of Pharmaceutical Sciences, 2015
Sodium alendronate is an antiresorptive drug used for the treatment of postmenopausal osteoporosis. However, its oral administration is associated with low bioavailability and gastroesophageal irritation.
Luana Mota Ferreira, Aline de Arce Velasquez, Scheila Rezende Schaffazick, Letícia Cruz   +3 more
doaj   +1 more source