Results 21 to 30 of about 157,317 (312)

Topiramate in Lennox-Gastaut Syndrome

Pediatric Neurology Briefs, 1999
The efficacy and safety of topiramate as adjunctive therapy for Lennox-Gastaut syndrome were studied in an 11-week multicenter, double-blind, placebo-controlled trial involving 98 patients, 1-30 years of age, and reported from the New Jersey-Robert Wood ...
J Gordon Millichap
doaj   +1 more source

Spinal Tuberculosis (Pott’s Disease)

Pediatric Neurology Briefs, 2012
Researchers at Great Ormond Street Hospital for Children and Institute of Child Health, London, UK reviewed their experience of childhood spinal tuberculosis (TB) over a 15-year period (1995-2010).
J Gordon Millichap
doaj   +1 more source

Family functioning and eating psychopathology in developmental restrictive eating disorders after Covid-19 lockdown

Eating and Weight Disorders
Purpose While the impact of Covid-19 lockdowns on family dynamics and eating behaviors has been widely studied, there is limited and conflicting evidence regarding families of children and adolescents with restrictive eating disorders (EDs).
C. Marchetto, M. Criscuolo, I. Croci, M. E. Bucci, A. Caramadre, M. C. Castiglioni, S. Vicari, V. Zanna   +7 more
doaj   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats

Translational Psychiatry
Psilocybin has shown promise as a novel pharmacological intervention for treatment of depression, where post-acute effects of psilocybin treatment have been associated with increased positive mood and decreased pessimism.
Elizabeth L. Fisher, Ryan Smith, Kyna Conn, Andrew W. Corcoran, Laura K. Milton, Jakob Hohwy, Claire J. Foldi   +6 more
doaj   +1 more source

Effect of Strength-Based Resilience on Patient's Length of Stay at the Renfrew Center for Eating Disorders

Women's Health Reports, 2022
Objective: Throughout past decades, physicians have sought to understand factors that contribute to severity of an eating disorder (ED). There is a potential relationship between patients' resilience and the recovery course of their disorder.
Kaitlin Sanzone, Daniel Short, John Gaughan, Lori Feldman-Winter   +3 more
doaj   +1 more source

Biomimetic 3D‐Printed Adaptive Hydrogel Bioadhesives Featuring Superior Infection Resistance for Challenging Tissue Adhesion, Hemostasis, and Healthcare

Advanced Materials, EarlyView.
Biomimetic 3D‐printed hydrogel bioadhesives (PTLAs) are designed to address the limitations of existing bioadhesives, offering solutions for challenging tissue adhesion and enhanced healthcare. These PTLAs feature robust wet/underwater tissue adhesion/sealing, superior freeze/pressure and infection resistance, and adaptive self‐healing/gelling capacity,
Qi Wu, Meenakshi Chauhan, Bassma Khamaisi, Eid Nassar‐Marjiya, Shady Farah   +4 more
wiley   +1 more source

Ghrelin Enhancer, the Latest Evidence of Rikkunshito

Frontiers in Nutrition, 2021
Rikkunshito is a Japanese herbal medicine (Kampo) that has been attracting attention and researched by many researchers not only in Japan but also worldwide. There are 214 rikkunshito articles that can be searched on PubMed by August 2021. The reason why
Chihiro Yamada, Tomohisa Hattori, Shunsuke Ohnishi, Hiroshi Takeda, Hiroshi Takeda   +4 more
doaj   +1 more source

Synergistic Modulation of Microglial Polarization by Acteoside and Ferulic Acid via Dual Targeting of Nrf2 and RORγt to Alleviate Depression‐Associated Neuroinflammation

Advanced Science, EarlyView.
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo, Qiancheng Mao, Xinyu Fang, Liuxuan Huang, Haoquan Tian, Wenguang Yang, Feiyue Zhou, Ke Ma   +7 more
wiley   +1 more source