Results 101 to 110 of about 2,009,667 (303)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Curso de ANOVA Multifactorial - Tema 1 - ANOVA Intro

, 2015
Introducción y conceptos de ...
Zubcoff, Jose
core  

Rational ANOVA Networks

CoRR
Deep neural networks typically treat nonlinearities as fixed primitives (e.g., ReLU), limiting both interpretability and the granularity of control over the induced function class. While recent additive models (like KANs) attempt to address this using splines, they often suffer from computational inefficiency and boundary instability.
Jusheng Zhang, Ningyuan Liu, Qinhan Lyu, Jing Yang, Keze Wang   +4 more
openaire   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

09 - ANOVA [PDF]

, 2016
Analisi della varianza (ANOVA): One-Way ANOVA, One-Way ANOVA per campioni appaiati, Two-Way ANOVA.
Plazzi, Federico
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inward foreign direct investment and transfer of environmentally sound technology in Angola

South African Journal of Science, 2016
Many developing countries have relied on foreign direct investment as a primary means to acquire technologies. However, there has been inadequate empirical research on the nexus between foreign direct investment and the transfer of environmentally sound ...
Albert E. Manyuchi
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A robust procedure for comparing multiple means under heteroscedasticity in unbalanced designs. [PDF]

, 2010
Investigating differences between means of more than two groups or experimental conditions is a routine research question addressed in biology. In order to assess differences statistically, multiple comparison procedures are applied.
Esther Herberich, Sikorski, Johannes, Torsten Hothorn, Herberich, Esther, Hothorn Torsten, Hothorn, Torsten, Herberich Esther, Johannes Sikorski, Sikorski Johannes   +8 more
core   +1 more source

Strengthening primary care mental health services – lessons from the South African HIV programme

South African Medical Journal
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J Dunlop, E Zibengwa, A E Manyuchi, C Chinyandura, T Mutsago, K S Magongoa, G Khoele, M Mabitsi, K Rees   +8 more
doaj   +1 more source