Results 101 to 110 of about 2,239,865 (298)
Southern African Journal of HIV Medicine, 2019 Background: The extent of disclosure of HIV status to children and adolescents and the context facilitating their disclosure process have received little attention.
Sabine L. van Elsland +6 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
BMC Infectious Diseases, 2019 Background Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are mostly asymptomatic, and important reservoir sites of infection as they often go undetected and may be more difficult to eradicate with recommended therapeutic ...
Johanna M. E. Venter +7 more
doaj +1 more source
CoRRDeep neural networks typically treat nonlinearities as fixed primitives (e.g., ReLU), limiting both interpretability and the granularity of control over the induced function class. While recent additive models (like KANs) attempt to address this using splines, they often suffer from computational inefficiency and boundary instability.
Jusheng Zhang +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
, 2021 Material de enseñanza para el aprendizaje del análisis con ANOVA con múltiples factores ortogonales. Factores fijos o aleatorios. Como funciona ANOVA. Qué estrategia seguir para el análisis.
Zubcoff, Jose
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Inward foreign direct investment and transfer of environmentally sound technology in Angola
South African Journal of Science, 2016 Many developing countries have relied on foreign direct investment as a primary means to acquire technologies. However, there has been inadequate empirical research on the nexus between foreign direct investment and the transfer of environmentally sound ...
Albert E. Manyuchi
doaj +1 more source