Results 91 to 100 of about 60,866 (284)
Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A
Phytotherapy Research, EarlyView.ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen +16 more
wiley +1 more source
Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function
Phytotherapy Research, EarlyView.Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng +8 more
wiley +1 more source
Sustainable Development, EarlyView.ABSTRACT Sustainable development transforms production systems, requiring integrated environmental, social, and economic strategies. Energy systems are key agro‐industrial supply chains in developing countries. Brazil's soybean supply chain impacts Gross Domestic Product, mainly through exports.
Aline Veronese da Silva +3 more
wiley +1 more source
782-B FID-007: nanoencapsulated paclitaxel derived from a novel nano-drug delivery platform
Journal for ImmunoTherapy of Cancer, 2023 William Witham
doaj +1 more source
Sustainable Development, EarlyView.ABSTRACT This study investigates how 14 sustainable consumption and production (SCP) factors interact across four service categories—Mass Service, Professional Service, Service Factory, and Service Shop—using interpretive structural modeling (ISM). ISM enables the identification and hierarchical classification of interdependencies among SCP factors in ...
Amanda Duarte Feitosa +4 more
wiley +1 more source
The Nexus Between Circular Economy and Sustainable Supply Chain Management: PRISMA Methodology
Sustainable Development, EarlyView.ABSTRACT The intersection of sustainable supply chain management (SSCM) and circular economy (CE) has attracted increasing academic and practical attention, emphasizing the need for integrated sustainability approaches. This study employs the PRISMA protocol and conceptualizes the CE–SSCM relationship as a dynamic system in which internal capabilities,
Feriel Barkaoui, Khaled Ben abdallah
wiley +1 more source
Regional Sustainability Assessment Under Risk and Uncertainty: A Water–Energy–Food Based Framework
Sustainable Development, EarlyView.ABSTRACT Regional sustainability assessment requires integrated structures that can examine the interactions between Water–Energy–Food (WEF) systems, socio‐economic risk conditions, and performance outcomes under uncertainty. This study proposes a multidimensional framework that combines a suitability index, composite sustainability indicators ...
Murat Oturakci
wiley +1 more source
Resource redeployment as an entry advantage in resource‐poor settings
Strategic Management Journal, EarlyView.Abstract Research Summary Scarcity of productive factors poses a challenge for firms entering underdeveloped regions. We theorize that incumbent firms can overcome scarcity of skilled human capital in local labor markets by redeploying workers from existing units.
Jasmina Chauvin +2 more
wiley +1 more source
Systems Research and Behavioral Science, EarlyView.ABSTRACT Generative artificial intelligence (GenAI) has emerged as a transformative force across business and society due to its ability to generate new content. This potential to reshape businesses introduces challenges and opportunities, necessitating a deeper understanding of GenAI's impact.
Symone G. S. Alcalá +3 more
wiley +1 more source