Results 111 to 120 of about 60,866 (284)

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Structured machine learning modeling to support conservation of deep‐sea benthic biodiversity

Conservation Biology, EarlyView.
Abstract Biodiversity monitoring programs need to deliver accurate, timely, and actionable predictions. To establish a predictive monitoring program for deep‐sea benthos of the Santos Basin, Brazil, we developed a two‐stage structured model that allowed comparison of biodiversity predictions obtained from environmental simulations (2M‐Sim).
Gustavo Fonseca, Danilo C. Vieira, Juliane C. Carneiro, Renato S. Carreira, Milena Ceccopieri, Thais N. Corbisier, Adriana Galindo Dalto, Alberto G. Figueiredo Jr., Fabiane Gallucci, Paula Gheller, Simone Brito de Jesus, Helena Passeri Lavrado, Letícia Lazzari, Eduardo Hilzendeger Marcon, Daniel Leite Moreira, Rafael Bendayan de Moura, Ellen Pape, Ana Cláudia Aoki Santarosa, João Regis dos Santos Filho, Silvia Helena de Mello e Sousa, Thaisa Marques Vicente, Luciana Erika Yaginuma, Cinthia Yamashita, Wandrey Watanabe   +23 more
wiley   +1 more source

Taraxacum Officinale (Dandelion) Roots Extract Mitigates Doxorubicin-Induced HematoCardiotoxicity in Male Albino Rats

Journal of Veterinary Medical Research, 2019
The present study was designed to evaluate the probable ameliorative effect of dandelion extract against doxorubicin hemato-cardiotoxicity. To accomplish this study, four groups of male albino rats (n=7) were used as follow, Group I: served as a ...
Dina R. S. Gad El-Karim
doaj  

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Psychological responses to interval and continuous exercise in people living with HIV: A single‐blind, counterbalanced, crossover study

HIV Medicine, EarlyView.
Abstract Aim This study compared acute psychological responses to a single session of low‐volume high‐intensity interval exercise (HIIE‐LV), high‐volume high‐intensity interval exercise (HIIE‐HV), and moderate‐intensity continuous exercise (MICE) in people living with HIV, and healthy controls using a randomized, counterbalanced crossover design ...
Phelipe Wilde, Victor S. de Queiros, Jason R. Jaggers, Angelo Sabag, Júlio M. Alves, Elaine Fernandes, Roberto F. C. Rocha, Paulo F. de Almeida‐Neto, Ronaldo Vagner Thomatieli‐Santos, Paulo Moreira Silva Dantas   +9 more
wiley   +1 more source

Dietary Sodium Reduction Reveals Aldosterone Dysregulation in Patients With Essential Hypertension [PDF]

J Clin Hypertens (Greenwich)
ABSTRACT Dietary sodium reduction affects blood pressure (BP), the renin‐angiotensin‐aldosterone system (RAAS) and natriuretic peptides. Whether baseline levels of these hormones impact BP response to sodium reduction remains unknown. Aldosterone dysregulation relates to higher cardiovascular risk, but the relation to sodium reduction has not been ...
Duus C, Nielsen S, Hornstrup B, Mose F, Bech J.   +4 more
europepmc   +2 more sources

Commercial clays in cosmetic formulations for hair care: Characterization and application to improve the mechanical properties of hair fibre

International Journal of Cosmetic Science, EarlyView.
The shampoo and conditioner bar formulations enhanced hair gloss, promoting softness, improved cuticle alignment, and effective protection of hair shafts against external aggressors. Findings from mechanical properties measurements indicate that the clay‐containing formulations enhance the mechanical strength of hair, contributing to stronger and more ...
João Pedro Gonçalves de Souza Soares, Melânia Lopes Cornélio, Fausthon Fred da Silva   +2 more
wiley   +1 more source

Bridging the implementation gap in MCABC inventory management: from a taxonomy to practical archetypes

International Transactions in Operational Research, EarlyView.
Abstract Despite increasing demands for resilient and sustainable supply chains, inventory management often relies on outdated single‐criterion analyses. While multi‐criteria ABC (MCABC) analyses provide a theoretically mature assessment of resilience‐sustainability‐benefit trade‐offs in inventory, their adoption remains limited due to fragmented ...
Lukas Grützner, Michael H. Breitner
wiley   +1 more source