Results 131 to 140 of about 138,806 (296)

Throughput Improving Model for Patients with Chest Pain in Heart Emergency Department

پیاورد سلامت, 2017
Background and Aim: Throughput improvement is a process that simultaneously increases the volume of services provided to patients, while decreasing the operating costs.
Mohammad Mehdi Sepehri, Sara Naderi, Mansoureh Naderi   +2 more
doaj  

Intellectual Solidarity and Reflexive Dislocation: Sociology in the Age of Global Authoritarianism

The British Journal of Sociology, EarlyView.
ABSTRACT This article contributes to current debates on the ethics of critical scholarship in an era of authoritarian consolidation and institutional erosion. It introduces intellectual solidarity as an ethical stance and reflexive dislocation as a methodological practice that together offer a grounded response to the complicities and constraints of ...
Salvador Santino Regilme
wiley   +1 more source

Monitoring African Megafauna in an Anthropogenic Landscape: A 15‐Year Case Study of the Vulnerable West African Giraffe

Animal Conservation, EarlyView.
We used pattern recognition software to correct misidentifications in a 15‐year photographic database of the last, vulnerable West African giraffe population in Niger. After revealing substantial methodological errors that had inflated population estimates by nearly 19%, we corrected individual encounter histories and applied capture‐mark‐recapture ...
Mara Vukelić, Ella W. White, Julian Fennessy, Abdoul Razack Moussa Zabeirou, Kateřina Gašparová, Simon Valle, Michael B. Brown, Thomas Rabeil, Karolína Brandlová   +8 more
wiley   +1 more source

Has Australia lost control of its tobacco and nicotine markets?

Addiction, EarlyView.
Abstract Background Australia has adopted two policies that the World Health Organization (WHO) recommends as best practice for tobacco control: it has steeply increased tobacco taxes since 2010 and only allowed access to nicotine vapes for medical use.
Ron Borland, James Martin, Edward Jegasothy, Ben Youdan, Wayne Hall   +4 more
wiley   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Structured machine learning modeling to support conservation of deep‐sea benthic biodiversity

Conservation Biology, EarlyView.
Abstract Biodiversity monitoring programs need to deliver accurate, timely, and actionable predictions. To establish a predictive monitoring program for deep‐sea benthos of the Santos Basin, Brazil, we developed a two‐stage structured model that allowed comparison of biodiversity predictions obtained from environmental simulations (2M‐Sim).
Gustavo Fonseca, Danilo C. Vieira, Juliane C. Carneiro, Renato S. Carreira, Milena Ceccopieri, Thais N. Corbisier, Adriana Galindo Dalto, Alberto G. Figueiredo Jr., Fabiane Gallucci, Paula Gheller, Simone Brito de Jesus, Helena Passeri Lavrado, Letícia Lazzari, Eduardo Hilzendeger Marcon, Daniel Leite Moreira, Rafael Bendayan de Moura, Ellen Pape, Ana Cláudia Aoki Santarosa, João Regis dos Santos Filho, Silvia Helena de Mello e Sousa, Thaisa Marques Vicente, Luciana Erika Yaginuma, Cinthia Yamashita, Wandrey Watanabe   +23 more
wiley   +1 more source

Mechanistic insights into HapC: A key enzyme in prodiginine biosynthesis in Hahella chejuensis

The FEBS Journal, EarlyView.
HapC catalyzes prodiginine biosynthesis through coordinated movements of its ATP‐binding, substrate‐binding, and catalytic‐swivel domains. The enzyme shows tolerance toward short‐chain MAP analogs, and docking analyses reveal key residues and structural features underlying its substrate flexibility.
Yueh‐Te Chan, Aden Dhana Rizkita, Hsin‐Ju Hsieh, Shu‐Fang Hsu, Tony Eight Lin, Wei‐Jan Huang, Kai‐Cheng Hsu, Sheila Nathan, Peiching Chang, Andrew H.‐J. Wang, Cheng‐Chung Lee   +10 more
wiley   +1 more source