Results 241 to 250 of about 407,443 (284)

CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia. [PDF]

Front Immunol
Nguyen CH, Zmajkovicova K, Sekirnik A, Taplin S, Defontis M, Bledsoe JR, Taveras AG, Karlsson L, Johnson R.   +8 more
europepmc   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency. [PDF]

JCI Insight
Hayes KM, Boldt K, Schnorr PJ, Bawa P, Abyazi ML, Ware MS, Gyimesi G, James M, Ko HM, Cunningham-Rundles C, Mizgerd JP, Mostoslavsky G, Kotton DN, Maglione PJ.   +13 more
europepmc   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

Diversity of Endophytic Fungi in Theobroma grandiflorum and their Potential for Biological Control of Witches' Broom Disease and Promotion of Cupuaçu Seedling Growth in the Amazon. [PDF]

Curr Microbiol
Santos JS, de Souza NT, da Silva Rodrigues T, Martins FJF, Dos Santos Prado L, Diniz FV, Viga ER, de Alcântara da Silva BK, Carvalho CM, Peters LP.   +9 more
europepmc   +1 more source

GLP-1 physiology and pharmacology along the gut-brain axis. [PDF]

J Clin Invest
Beutler LR.
europepmc   +1 more source

Personality Traits and Psychological Well-Being: Association Within the "Seguimiento Universidad de Navarra" (SUN) Cohort. [PDF]

Personal Ment Health
Basterra-Gortari V, Gil-Conesa M, Sayón-Orea C, Lahortiga-Ramos F, De la Fuente-Arrillaga C, Martínez-González MA, Bes-Rastrollo M.   +6 more
europepmc   +1 more source

Prevalence of polypharmacy and drug interactions in geriatric patients: A cross-sectional study from India. [PDF]

PLoS One
Khaiser UF, Sultana R, Das R, Alzahrani SG, Kannan M, Newigy MK, Quadri MSA, Shaikh MA, Shaikh FM, Fareed M.   +9 more
europepmc   +1 more source

β-adrenergic receptors modulate CA1 population coding and synaptic plasticity during cumulative spatial memory formation and updating. [PDF]

Sci Rep
Shendye N, Haubrich J, Weber JP, Hagena H, Manahan-Vaughan D.   +4 more
europepmc   +1 more source