Results 241 to 250 of about 182,741 (305)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Caffeine, skeletal muscle signalling, and exercise adaptation: a narrative review separating acute ergogenic effects from chronic remodelling. [PDF]

Front Physiol
Liu Z, Zheng H, Deng H, Wang M, Du W, Chen M, Zhang Z, Wu B.   +7 more
europepmc   +1 more source

The BnTFL1‐BnJAM3‐BnSWEETs Module Orchestrates Seed Storage Reserve Accumulation in Brassica napus

Advanced Science, EarlyView.
BnaC03.TFL1 and BnaA01.JAM3 form a complex that facilitates the transport of soluble sugars from the seed coat to the embryo by directly activating the expression of BnSWEETs. Furthermore, BnaC03.TFL1 and BnaA01.JAM3 work cooperatively to promote soluble sugar and oil production while suppressing protein deposition.
Jianjun Wang, Zijin Liu, Minshan Jin, Junting Liu, Shihao Wei, Dengmao Yang, Saiqi Yang, Yuan Guo, Mingxun Chen   +8 more
wiley   +1 more source

Antagonizing

The American Historical Review
openaire   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

GIPR signaling modulates PYY-induced hypophagia and malaise in rodents. [PDF]

Mol Metab
Borner T, Pataro AM, Curtis GR, Alonso B, Hu J, Fortin SM, Koul-Tiwari R, Hughes E, Kong JX, Jordan E, Barnes R, Bernardo B, Gardner M, Ma W, Gosset JR, Esquejo RM, Fortin JP, De Jonghe BC, Bence KK, Hayes MR.   +19 more
europepmc   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Agronomic biofortification in crops with Zn: the zinc-iron interaction dilemma. [PDF]

Front Plant Sci
Debnath S, Saha S, Adhikary S, Mal S, Chakraborty M, Kumar S, Ram A, Khanam R, Ghosh D, Dash B, Padhan D, Mukherjee S, Yadav A, Biplab, Biswas T, Das S, Reddy MK, Sinha A, Batabyal K, Sarkar D, Mandal B.   +20 more
europepmc   +1 more source

Pain Outcome Determines the Sensitivity to Peripheral Opioid Antagonism of Morphine, Ibuprofen, and Their Combination in Laparotomized Mice. [PDF]

Pharmaceutics
Hasoun MA, Santos-Caballero M, Huerta MÁ, Robles-Funes M, Puerto-Moya A, Ruiz-Cantero MC, Cobos EJ, González-Cano R.   +7 more
europepmc   +1 more source

SAR-Guided Scaffold Innovation of Selective V₂R Antagonists: Therapeutic Frontiers in ADPKD. [PDF]

ACS Med Chem Lett
Shi H, Li Y, Liang SH.
europepmc   +1 more source