Results 71 to 80 of about 325,108 (297)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
, 1990 Some of the various categories of issues that must be considered in the selection and design of spacecraft antennas for a Personal Access Satellite System (PASS) are addressed, and parametric studies for some of the antenna concepts to help the system ...
Cramer, Paul +3 more
core +1 more source
Representation theory for high-rate multiple-antenna code design [PDF]
, 2000 Multiple antennas can greatly increase the data rate and reliability of a wireless communication link in a fading environment, but the practical success of using multiple antennas depends crucially on our ability to design high-rate space-time ...
Hassibi, Babak +3 more
core +4 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
IEEE Access, 2018 In this paper, an antenna interference cancellation chip (AICC) with a high-pass response is proposed to mitigate the mutual coupling of two antennas resonating in contiguous frequency bands.
Luyu Zhao +5 more
doaj +1 more source
Sensors, 2021 Direction finding (DF) systems are used to determine the direction-of-arrival (DoA) of electromagnetic waves, thus allowing for the tracking of RF sources. In this paper, we present an alternative formulation of antenna arrays for modeling DF systems. To
Bernardo Fabiani +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Orthogonal Genetic Algorithm for Planar Thinned Array Designs
International Journal of Antennas and Propagation, 2012 An orthogonal genetic algorithm (OGA) is applied to optimize the planar thinned array with a minimum peak sidelobe level. The method is a genetic algorithm based on orthogonal design.
Li Zhang +3 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source