Results 51 to 60 of about 271,114 (307)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Anterior chamber depth during hemodialysis

Clinical Ophthalmology, 2013
Carolina Pelegrini Barbosa Gracitelli,1 Francisco Rosa Stefanini,1 Fernando Penha,1 Miguel Ângelo Góes,2 Sérgio Antonio Draibe,2 Maria Eugênia Canziani,2 Augusto Paranhos Junior1 1Ophthalmology Department, 2Division of ...
Gracitelli CPB, Stefanini FR, Penha F, Góes MA, Draibe SA, Canziani ME, Paranhos Jr A   +6 more
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Effect of surgical microscope and illuminated chopper on anterior chamber temperature

BMC Ophthalmology, 2023
Background To evaluate the effect of the light intensity of the surgical microscope and illuminated chopper on the anterior chamber temperature. Study design Experimental study.
Youngsub Eom, Young Joo Lee, Jong Suk Song, Hyo Myung Kim, Dong Heun Nam   +4 more
doaj   +1 more source

GNATHOSTOMIASIS OF THE ANTERIOR CHAMBER

Indian Journal of Medical Microbiology, 2007
Ocular involvement with Gnathostoma spinigerum occurs years after the initial infection that is acquired by ingestion of poorly cooked, pickled seafood or water contaminated with third stage larvae. Here we report a case of gnathostomiasis of the left eye of a 32-year-old lady hailing from Meghalaya, India. Her vision had deteriorated to hand movement.
Barua, P, Hazarika, NK, Barua, N, Barua, CK, Choudhury, B   +4 more
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Low Iris and Anterior Chamber Volume Associated with Deepening after Laser Peripheral Iridotomy in Primary Angle Closure Suspects [PDF]

, 2017
Purpose: To evaluate the association between baseline ocular variables and the opening of the anterior chamber angle by laser peripheral iridotomy (LPI) in primary angle closure suspects (PACS) using a new Fourier-domain swept-source anterior segment ...
Amouhashemi, Nassim, Esfandiari, Hamed, Jadidi, Khosrow, Loewen, Nils A., Pakravan, Mohammad, Torkian, Pooya, Yaseri, Mehdi   +6 more
core  

Fatores preditivos para formação de fibrina na câmara anterior após cirurgia vitreorretiniana [PDF]

, 2014
Purpose: The aim of this study was to investigate possible predictive factors related to anterior chamber fibrin formation after vitreoretinal surgery in a large series of patients.Methods:The data of 185 eyes of 185 patients submitted to vitreoretinal ...
Bastos, Ronaldo Rocha, Costa, Carolina Ferreira, Costa-cunha, Luciana Virgínia Ferreira, Cunha, Leonardo Provetti, Monteiro, Mário Luiz Ribeiro, Prata, Tiago dos Santos   +5 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Repeatability and comparison of clinical techniques for anterior chamber angle assessment [PDF]

, 2015
Purpose To assess the repeatability of gonioscopy, van Herick method and anterior segment Optical Coherence Tomography (AS-OCT) and determine the agreement between these techniques within a community optometry setting. Methods Gonioscopy, van Herick
Agarwal, R.K., Campbell, P., Evans, B. J. W., Marshall, L. K., Redmond, T.   +4 more
core   +2 more sources