Results 41 to 50 of about 82,972 (297)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Acute bilateral simultaneous angle closure glaucoma after topiramate administration: a case report [PDF]

, 2008
Introduction A case of severe acute bilateral angle closure glaucoma with complete visual loss after oral topiramate therapy. Case presentation A 34 year-old woman developed bilateral severe visual loss 2 days after doubling the dosage of topiramate. Her
Kakarla V Chalam, Tina Tillis, Farhana Syed, Swati Agarwal, Vikram S Brar, JT Banta, J Levy, FW Fraunfelder, JE Craig, FA Medeiros, SD Silberstein, E Eisenberg, P Raskin, N Celebisoy, BA Johnson   +14 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Agreement between ANTERION and IOLMaster700 in ocular biometric measurements in a Brazilian population [PDF]

Revista Brasileira de Oftalmologia
Objective: To evaluate the agreement of biometric parameters measured by the ANTERION and IOLMaster700 devices in a Brazilian population, considering statistical differences and their clinical relevance.
Luís Armando Vitorino Alves de Souza Gondim, Roberta Kern Menna Barreto, José Maurilio Tavares de Lucena, Bernardo Kaplan Moscovici, Ivan Corso Teixeira   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Evaluation of Cornea and Anterior Chamber Using Pentacam in Pediatric Cases

Türk Oftalmoloji Dergisi, 2011
Purpose: To evaluate the anterior segment structures using Pentacam in pediatric cases. Material and Method: One hundred sixty-two eyes (study group) of 81 healthy children who attended our clinic were compared with 114 eyes (control group) of 57 ...
Melis Palamar Onay, Sait Eğrilmez, Önder Üretmen, Ayşe Yağcı, Süheyla Köse   +4 more
doaj   +1 more source

Live imaging of whole mouse embryos during gastrulation : migration analyses of epiblast and mesodermal cells [PDF]

, 2013
During gastrulation in the mouse embryo, dynamic cell movements including epiblast invagination and mesodermal layer expansion lead to the establishment of the three-layered body plan.
Ichikawa, Takehiko, Kajiura-Kobayashi, Hiroko, Keller, Philipp J., Mochizuki, Atsushi, Nakazato, Kenichi, Nonaka, Shigenori, Stelzer, Ernst H. K.   +6 more
core   +3 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Low Iris and Anterior Chamber Volume Associated with Deepening after Laser Peripheral Iridotomy in Primary Angle Closure Suspects [PDF]

, 2017
Purpose: To evaluate the association between baseline ocular variables and the opening of the anterior chamber angle by laser peripheral iridotomy (LPI) in primary angle closure suspects (PACS) using a new Fourier-domain swept-source anterior segment ...
Amouhashemi, Nassim, Esfandiari, Hamed, Jadidi, Khosrow, Loewen, Nils A., Pakravan, Mohammad, Torkian, Pooya, Yaseri, Mehdi   +6 more
core