Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials
British Journal of Pharmacology, EarlyView.Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen +2 more
wiley +1 more source
Transcriptome Profiling of the Anterior Cingulate Cortex in a CFA-Induced Inflammatory Pain Model Identifies ECM-Related Genes in a Model of Rheumatoid Arthritis. [PDF]
Genes (Basel)Xie GX +7 more
europepmc +1 more source
Dissociable Neural Responses Related to Pain Intensity, Stimulus Intensity, and Stimulus Awareness within the Anterior Cingulate Cortex: A Parametric Single-Trial Laser Functional Magnetic Resonance Imaging Study [PDF]
, 2002 Christian Büchel +5 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2020 Abstract Objectives While preliminary evidence suggests that noninvasive vagal nerve stimulation (nVNS) may enhance cognition, to our knowledge, no study has directly assessed the effects of nVNS on brain function and cognitive performance in healthy individuals.
Ruth Klaming +3 more
wiley +1 more source
Author Correction: Beta activity in human anterior cingulate cortex mediates reward biases. [PDF]
Nat CommunXiao J +20 more
europepmc +1 more source
Spike–fast activity interplay: A gateway to seizure
Epilepsia, EarlyView.Abstract Objective The transition from interictal discharges to ictal high‐frequency activity (HFA) remains poorly understood. We investigated whether spike‐associated high‐frequency oscillations (Sp‐HFOs) during interictal and preictal periods contribute to the emergence of ictal HFA.
Thandar Aung +2 more
wiley +1 more source
Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults [PDF]
Yu Chen +5 more
openalex +1 more source
Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery
Epilepsia, EarlyView.Abstract Objective Memory impairments are common in neurological disorders, especially drug‐resistant epilepsy, where cognitive deficits such as accelerated long‐term forgetting may occur before surgery due to interictal/ictal discharges, antiseizure medications, and disease progression.
Barbora Matouskova +9 more
wiley +1 more source