Results 41 to 50 of about 1,222,115 (287)

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

Triple-Bundle Medial Collateral Ligament Reconstruction: The Medial Arrow Technique

Arthroscopy Techniques
Medial knee injuries are common and sometimes overlooked in cases of anterior cruciate ligament injuries. Persistent anteromedial rotatory instability can lead to chronic pain and later anterior cruciate ligament reconstruction failure.
Hesham Mohamed Gawish, M.D., Mohamed Abdelmonsef Ibrahim Elghaish, M.Ch Ortho, Waleed Hamed Hamed Ebrahim Aziz, M.Ch Ortho, Emam Mohamed Ahmed Emam Ahmed, M.Ch Ortho, Ahmed Hassan Saad Abou Helwo, M.Ch Ortho, Ahmed Hassan Taha Waly, M.D.   +5 more
doaj   +1 more source

Femoral Physeal-Sparing Anterior Cruciate Ligament Reconstruction Using the Iliotibial Band: Over-The-Top Technique

Arthroscopy Techniques, 2020
Anterior cruciate ligament injuries are increasingly frequent in skeletally immature patients. However, treatment within this subpopulation remains controversial.
Felipe Galvão Abreu, M.D., Charles Pioger, M.D., Florent Franck, M.D., Benjamin Freychet, M.D., Thais D. Vieira, M.D., Bertrand Sonnery-Cottet, M.D.   +5 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

The top 100 most impactful articles on the anterior cruciate ligament: An altmetric analysis of online media

SAGE Open Medicine, 2022
Objectives: To identify the top 100 most impactful anterior cruciate ligament articles in online media as measured by the Altmetric Attention Score and compare their characteristics to the most-cited anterior cruciate ligament articles in the scientific ...
Matthew D Civilette, William R Rate, Brett D Haislup, Andrew S Cohen, Lyn Camire, Blake M Bodendorfer, Heath P Gould   +6 more
doaj   +1 more source

Injury Risk Estimation Expertise: Interdisciplinary Differences in Performance on the ACL Injury Risk Estimation Quiz [PDF]

, 2015
Background: Simple observational assessment of movement is a potentially low-cost method for anterior cruciate ligament (ACL) injury screening and prevention.
Cokely, E., Petushek, Erich J., Paul Ward, Petushek, E., Cokely, Edward T., Myer, G., Erich J. Petushek, Myer, Gregory D., Gregory D. Myer, Edward T. Cokely, Ward, Paul, Ward, P.   +11 more
core   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Knee Medial Complex Dissection to Expose the Anterior Oblique Ligament

Arthroscopy Techniques
Recently, new studies have shown an important role for the medial ligament complex in anterior cruciate ligament injuries. The study of the structures present in this complex is of crucial importance in orthopaedic surgical practice, seeking to ...
Pedro Baches Jorge, M.D., Ph.D., David Bonini Vieira Campanhã, M.D., Filip Brunčák, St., Mirna Duarte Barros, M.D., Ph.D., Camilo Partezani Helito, M.D., Ph.D., Diego Escudeiro de Oliveira, M.D.   +5 more
doaj   +1 more source