Results 51 to 60 of about 1,162,124 (282)

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Reverse Segond fracture and associated knee injuries: A case report and review of 13 published cases

Acta Orthopaedica et Traumatologica Turcica, 2016
Reverse Segond fracture is originally described as an indirect radiographic clue for a specific injury complex of the knee joint that includes posterior cruciate ligament (PCL) rupture and medial meniscal tear.
Ozkan Kose, Selahattin Ozyurek, Adil Turan, Ferhat Guler   +3 more
doaj   +1 more source

Tibiofemoral and patellofemoral joint 3D-kinematics in patients with posterior cruciate ligament deficiency compared to healthy volunteers [PDF]

, 2012
Background: The posterior cruciate ligament (PCL) plays an important role in maintaining physiological kinematics and function of the knee joint. To date mainly in-vitro models or combined magnetic resonance and fluoroscopic systems have been used for ...
Ulrich Lenze, Thomas Stein, Pohlig, Florian, Frederic Welsch, Florian Pohlig, Graichen, Heiko, Lenze, Ulrich, Stefan Hinterwimmer, Heiko Graichen, Rainer Burgkart, Burgkart, Rainer, Ruediger von Eisenhart-Rothe, Eisenhart-Rothe, Rüdiger von, Hinterwimmer, Stefan, Stein, Thomas, Welsch, Frederic   +15 more
core   +2 more sources

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Knee Medial Complex Dissection to Expose the Anterior Oblique Ligament

Arthroscopy Techniques
Recently, new studies have shown an important role for the medial ligament complex in anterior cruciate ligament injuries. The study of the structures present in this complex is of crucial importance in orthopaedic surgical practice, seeking to ...
Pedro Baches Jorge, M.D., Ph.D., David Bonini Vieira Campanhã, M.D., Filip Brunčák, St., Mirna Duarte Barros, M.D., Ph.D., Camilo Partezani Helito, M.D., Ph.D., Diego Escudeiro de Oliveira, M.D.   +5 more
doaj   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Suturing the Anterior Cruciate Ligament Using a No. 16 Intravenous Catheter Needle in Avulsion Anterior Cruciate Ligament Injury

Arthroscopy Techniques, 2020
Avulsion anterior cruciate ligament injuries are more common in pediatric patients. There are several methods of fixation available for these injuries (tibial intercondylar eminence fractures), such as the pullout suture technique, screw fixation, and ...
Korakot Maliwankul, M.D., Chaiwat Chuaychoosakoon, M.D.   +1 more
doaj   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Comparative Analysis of Neuromuscular Activation Patterns Associated with Force between Semi-Professional Female Soccer Players with Previous Anterior Cruciate Ligament Surgery and Healthy Players in Thigh Musculature Related to Valgus Collapse

Applied Sciences
This study investigates electromyography activation and force development differences in key lower limb muscles between female football players with previous anterior cruciate ligament injuries compared with healthy players.
Loreto Ferrández-Laliena, Rocío Sánchez-Rodríguez, Lucía Vicente-Pina, María Orosia Lucha-López, Mira Ambrus, César Hidalgo-García, Sofía Monti-Ballano, José Miguel Tricás-Moreno   +7 more
doaj   +1 more source

Multiligament Reconstruction of the Knee in the Setting of Knee Dislocation With a Medial-Sided Injury

Arthroscopy Techniques, 2017
Multiple ligament knee injuries are complex pathologies that often result from traumatic knee dislocations. Both a high level of suspicion and a thorough clinical and radiographic examination are mandatory to diagnose and identify all injured structures.
Marcio B. Ferrari, M.D., Jorge Chahla, M.D., Justin J. Mitchell, M.D., Gilbert Moatshe, M.D., Jacob D. Mikula, B.S., Daniel Cole Marchetti, B.A., Robert F. LaPrade, M.D., Ph.D.   +6 more
doaj   +1 more source