Results 161 to 170 of about 13,480 (263)

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

open access: yesAdvanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin   +17 more
wiley   +1 more source

Spatial‐Wavelength Multiplexing Error‐Controlled Photonic Analog Computing System

open access: yesAdvanced Science, EarlyView.
A novel photonic integrated circuit prototype implementing the concept of general‐purpose analog computing and demonstrate its capability in radio frequency applications. The chip features a multichannel architecture and performs fully optical analog computation with frequency‐domain parallel processing. An FPGA‐based error‐correction algorithm aims to
Tao Zhu   +15 more
wiley   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

open access: yesAdvanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan   +10 more
wiley   +1 more source

Analyzing effects on anterior open bite in twins by PLS-SEM and sobel test. [PDF]

open access: yesClin Oral Investig
Birant S   +5 more
europepmc   +1 more source

Tunable Switching Mechanisms in HfZrO2‐Based Tunnel Junctions for High‐Performance Synaptic Arrays

open access: yesAdvanced Science, EarlyView.
This work demonstrates hybrid switching in engineered HZO‐based FTJs, enabled by controlled interlayer design and oxygen scavenging dynamics. The combined switching mechanism produces robust multilevel conductance states in large crossbar arrays, offering a materials‐driven pathway toward scalable in‐memory computing with enhanced tunability and ...
Jiwon You   +8 more
wiley   +1 more source

Strategic treatment planning for anterior open bite: A comprehensive approach. [PDF]

open access: yesJ Dent Sci
Hsu JY   +5 more
europepmc   +1 more source

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy