Results 131 to 140 of about 1,757,177 (283)
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Advanced Science, EarlyView.Nanoscale secondary ion mass spectrometry (Nano SIMS) is established as a powerful analytical tool to visualize and quantify the membrane fouling layers. ABSTRACT Membrane technology has garnered considerable attention for applications in wastewater treatment and resource recovery. Nevertheless, membrane fouling remains a major barrier, yet the lack of
Mengfei Wu +4 more
wiley +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen +7 more
wiley +1 more source
Advanced Science, EarlyView.Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan +10 more
wiley +1 more source
Clinical Ophthalmology, 2013 Nursal Melda Yenerel,1 Raciha Beril Kucumen,2 Ebru Gorgun3 1Haydarpasa Numune Research and Training Hospital, Istanbul, Turkey; 2Yeditepe University Medical Faculty, Department of Ophthalmology, Istanbul, Turkey; 3Dunya Goz Eye Hospital, Istanbul, Turkey
Yenerel NM, Kucumen RB, Gorgun E
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4 - Conjunctival pathologic conditions
This chapter will discuss how the use of anterior segment optical coherence tomography (AS-OCT) can aid in the diagnosis, treatment planning, and surveillance for commonly encountered conjunctival pathology. Pathologies presented include benign entities (
Wall, Sarah L. +2 more
core +1 more source
Advanced Science, EarlyView.Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu +7 more
wiley +1 more source
Anterior chamber angle in aniridia with and without glaucoma
Clinical Ophthalmology, 2019 Asima Bajwa,1 Eitan Burstein,1 Robert M Grainger,1,2 Peter A Netland11Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA; 2Department of Biology, University of Virginia, Charlottesville, VA, USAPurpose: We ...
Bajwa A +3 more
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