Results 91 to 100 of about 38,638 (261)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

The impact of graves’ orbitopathy on anterior segment structures and choroidal parameters

open access: yesBMC Ophthalmology
To evaluate Schlemm's canal (SC) dimensions and choroidal vascularity in patients with Graves' orbitopathy (GO+), and to compare the findings with those of patients with Graves' disease (GD) without orbitopathy (GO-) and healthy controls using optical coherence tomography (OCT); additionally, to investigate the potential impact of these anatomical and ...
Neslihan Sevimli   +3 more
openaire   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

POSTERIOR CHAMBER PHAKIC IOL SIZING. PART I. A NEW ALGORITHM OF SULCUS CILIARIS DIAMETER ASSESSMENT USING ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY

open access: yesОфтальмохирургия, 2015
Purpose. To study the effectiveness of a new algorithm in measurement of sulcus ciliaris diameter by the method of anterior segment optical coherence tomography (AS-OCT). Material and methods. Thirty two patients (32 eyes) with high myopia (age range: 19
B. E. Malyugin   +5 more
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Posterior chamber phakic IOL sizing. Part I. A new algorithm of sulcus ciliaris diameter assessment using anterior segment optical coherence tomography

open access: yesОфтальмохирургия, 2013
Purpose. To study the effectiveness of a new algorithm in measurement of sulcus ciliaris diameter by the method of anterior segment optical coherence tomography (AS-OCT). Material and methods. Thirty two patients (32 eyes) with high myopia (age range:
B.E. Malyugin   +5 more
doaj  

Functional Versus Anatomic Assessment of Myocardial Bridging by Intravascular Ultrasound: Impact of Arterial Compression on Proximal Atherosclerotic Plaque

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe presence of a myocardial bridge (MB) has been shown to promote atherosclerotic plaque formation proximal to the MB, presumably because of hemodynamic disturbances provoked by retrograde blood flow toward this segment in cardiac systole.
Ryotaro Yamada   +9 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

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