Results 71 to 80 of about 2,733,104 (305)

Pediatric cornea and anterior segment imaging

As a noninvasive, well-tolerated imaging modality, anterior segment optical coherence tomography (AS-OCT) can be instrumental for visualization of pediatric cornea, ocular surface, and anterior segment abnormalities.
Ali, Asim, Zhu, Angela Y.
core   +1 more source

Anterior segment optical coherence tomography (AS-OCT) image analysis methods and applications: A systematic review

, 2022
Background: Anterior segment optical coherence tomography (AS-OCT) constitutes an important imaging modality to examine the anterior eye, which is commonly used in research and clinical practice.
Garcia Marin, YF, Alonso-Caneiro, D, Collins, MJ, Vincent, SJ   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure

Journal of Ophthalmology, 2019
Purpose. To investigate demographic and anatomical factors associated with a reduction in endothelial cell density (ECD) after phacoemulsification (PE) for the treatment of primary angle closure (PAC). Methods.
Carlo Alberto Cutolo, Chiara Bonzano, Carlo Catti, Alessandro Bagnis, Riccardo Scotto, Letizia Negri, Sara Olivari, Francesca Cappelli, Carlo Enrico Traverso   +8 more
doaj   +1 more source

Refractive changes of a new asymmetric intracorneal ring segment with variable thickness and base width: A 2D finite-element model.

PLoS ONE, 2021
PurposeTo evaluate the local geometric effects of a unilateral intrastromal ring segment with a combined variation of ring thickness and base width in a finite element simulation, and to compare it against the isolated effect of thickness or base width ...
Gonzalo García de Oteyza, Juan Álvarez de Toledo, Rafael I Barraquer, Sabine Kling   +3 more
doaj   +1 more source

Toxic Anterior Segment Syndrome Related to Viscoelastic Substance

, 2014
Objectives: To evaluate the etiologic factors of toxic anterior segment syndrome (TASS) outbreak after uneventful cataract surgery, to discuss the treatment plan, and to assess the response to medical therapy.
Ayşe Gül Altıntaş, Gültekin Köklü, Sibel Polat, Meryem Yaşar, Çiğdem Can   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Deep learning-based anterior segment identification and parameter assessment of primary angle closure disease in ultrasound biomicroscopy images

BMJ Open Ophthalmology
Purpose To develop an artificial intelligence algorithm to automatically identify the anterior segment structures and assess multiple parameters of primary angle closure disease (PACD) in ultrasound biomicroscopy (UBM) images.Design Development and ...
Xingzhi Sun, Guotong Xie, Kun Lv, Xiaoyue Zhang, Bin Lv, Yuan Ni, Yao Ma, Fangting Li, Kangyi Yang, Jiayin Qin, Huijuan Wu   +10 more
doaj   +1 more source

Correlation Between Anterior Chamber Volume and Corneal Biomechanical Properties in Human Eyes

Frontiers in Bioengineering and Biotechnology, 2019
Purpose: To investigate the correlation between anterior chamber volume (ACV) and corneal biomechanical properties in healthy and primary angle closure (PAC) eyes.Methods: A total of 79 eyes from 55 participants were enrolled in this study, including 24 ...
Xinhan Cui, Yujing Yang, Yue Li, Feifei Huang, Yujin Zhao, Huiyu Chen, Jianjiang Xu, Alireza Mashaghi, Jiaxu Hong, Jiaxu Hong, Jiaxu Hong, Jiaxu Hong   +11 more
doaj   +1 more source