Results 71 to 80 of about 88,343 (292)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
PLoS ONE, 2021 PurposeTo evaluate the local geometric effects of a unilateral intrastromal ring segment with a combined variation of ring thickness and base width in a finite element simulation, and to compare it against the isolated effect of thickness or base width ...
Gonzalo García de Oteyza +3 more
doaj +1 more source
Low impact weight-bearing exercise in an upright posture achieves greater lumbopelvic stability than overground walking [PDF]
, 2013 The aim of this study was to determine the kinematic differences between movements on a new exercise device (EX) that promotes a stable trunk over a moving, unstable base of support, and overground walking (OW).
Caplan, Nick +2 more
core +3 more sources
Altered Anterior Segment Biometric Parameters in Mice Deficient in SPARC
Investigative Opthalmology & Visual Science, 2017 Secreted protein acidic and rich in cysteine (SPARC) and Hevin are structurally related matricellular proteins involved in extracellular matrix assembly. In this study, we compared the anterior chamber biometric parameters and iris collagen properties in SPARC-, Hevin- and SPARC-/Hevin-null with wild-type (WT) mice.The right eyes of 53 WT, 35 SPARC ...
Ho, Henrietta +8 more
openaire +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Kerala Journal of Ophthalmology, 2022 Purpose: The aim of the study was to evaluate the inter instrument agreement between gonioscopy and anterior segment optical coherence tomography (AS-OCT) in the assessment of the anterior chamber angle (ACA) in eyes with all Van Herick's grades. Methods:
K Jaseena, P S Rekha
doaj +1 more source
3D reconstruction of ribcage geometry from biplanar radiographs using a statistical parametric model approach [PDF]
, 2014 Rib cage 3D reconstruction is an important prerequisite for thoracic spine modelling, particularly for studies of the deformed thorax in adolescent idiopathic scoliosis.
AUBERT, Benjamin +4 more
core +2 more sources
Deep Learning-based Quantification of Anterior Segment OCT Parameters
Ophthalmology ScienceTo develop and validate a deep learning algorithm that could automate the annotation of scleral spur (SS) and segmentation of anterior chamber (AC) structures for measurements of AC, iris, and angle width parameters in anterior segment OCT (ASOCT) scans.Cross-sectional study.Data from 2 population-based studies (i.e., the Singapore Chinese Eye Study ...
Zhi Da Soh +10 more
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of Ophthalmology, 2019 Purpose. To investigate demographic and anatomical factors associated with a reduction in endothelial cell density (ECD) after phacoemulsification (PE) for the treatment of primary angle closure (PAC). Methods.
Carlo Alberto Cutolo +8 more
doaj +1 more source