Results 61 to 70 of about 2,733,104 (305)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Evaluation of Iris Melanoma with Anterior Segment Optical Coherence Tomography

, 2017
Anterior segment optical coherence tomography (AS-OCT) is a relatively new imaging modality that allows assessment of anterior segment structures. AS-OCT enables the differentiation of benign and malignant tumors through the evaluation of lesion size ...
Ahmet Kaan Gündüz, Mehtap Arslantürk Eren, Eren Aslantürk, Mehtap, Gündüz, Özlenen Ömür, Gündüz, Ahmet Kaan, Özlenen Ömür Gündüz   +5 more
core   +1 more source

Ophthoselfie: Detailed Self-imaging of Cornea and Anterior Segment by Smartphone [PDF]

, 2017
Objectives: To describe the ophthoselfie, a method by which everyone can take detailed self-images of the cornea and anterior segment with a smartphone.
Abdullah Kaya, Kaya, Abdullah
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Anterior Segment Surgeries and Dry Eye; Diagnosis and Therapeutic Approach

, 2012
Parallel to the frequent application of anterior segment surgical techniques, the frequency of dry eye disease is increasing. Dry eye is a multifactorial condition that affects the surface of the eye and induces an inflammatory response.
Banu Öncel, İlkay Kılıç, Yonca A. Akova   +2 more
core   +1 more source

The Effect of Topical Cyclopentolate on Anterior Segment Parameters in Patients with Keratoconus

Turkish Journal of Ophthalmology, 2019
To investigate the effect of cycloplegia on anterior segment structures in keratoconus and forme fruste keratoconus patients using corneal topography.In this study, 40 patients with keratoconus (group 1), 40 patients with forme fruste keratoconus (group 2), and 40 healthy subjects (group 3) were evaluated prospectively. Flat keratometry (K) value (K1),
Ahmet Kırgız, Sevil Karaman Erdur, Semih Çakmak, Funda Dikkaya, Rukiye Aydın   +4 more
openaire   +3 more sources

Does graves ophthalmopathy affect anterior segment parameters?

Annals of Medical Research, 2021
Aim: To evaluate whether anterior segment parameters (ASPs) differ between patients with Graves’s ophthalmopathy (GO) and healthy individuals. Materials and Methods: In a case-control study, 62 patients with GO and 45 healthy sex- and age-matched individuals were compared for ASPs obtained from Scheimpflug camera imaging (Sirius, Florence, Italy). The
Berkay Akmaz, Deniz Kilic, Fahrettin Akay, Soner Guven, Yusuf Guven, Baris Pamuk   +5 more
openaire   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Anterior segment optical coherence tomography: A clinically-oriented atlas

Anterior Segment Optical Coherence Tomography: A Clinically-Oriented Atlas introduces a wide range of clinical applications of anterior segment OCT for the diagnosis, follow up, and assessment of medical and surgical treatments and critical interventions.
Akova, Berna, Baykara, Mehmet, Kibritçioğlu, Mehmet Ömer   +2 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source