Results 61 to 70 of about 38,638 (261)

Correlation of vitreous chamber depth with ocular biometry in high axial myopia

Indian Journal of Ophthalmology, 2022
Purpose: The proportion of axial length (AL) occupied by vitreous chamber depth (VCD), or VCD:AL, consistently correlates to ocular biometry in the general population. Relation of VCD:AL to ocular biometry in high myopia is not known. The purpose of this
Anusha Paritala, Brijesh Takkar, Nripen Gaur, Deepak Soni, Mohammad Hasnat Ali, Anubha Rathi   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Does graves ophthalmopathy affect anterior segment parameters?

Annals of Medical Research, 2021
Aim: To evaluate whether anterior segment parameters (ASPs) differ between patients with Graves’s ophthalmopathy (GO) and healthy individuals. Materials and Methods: In a case-control study, 62 patients with GO and 45 healthy sex- and age-matched individuals were compared for ASPs obtained from Scheimpflug camera imaging (Sirius, Florence, Italy). The
Berkay Akmaz, Deniz Kilic, Fahrettin Akay, Soner Guven, Yusuf Guven, Baris Pamuk   +5 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Refractive changes of a new asymmetric intracorneal ring segment with variable thickness and base width: A 2D finite-element model.

PLoS ONE, 2021
PurposeTo evaluate the local geometric effects of a unilateral intrastromal ring segment with a combined variation of ring thickness and base width in a finite element simulation, and to compare it against the isolated effect of thickness or base width ...
Gonzalo García de Oteyza, Juan Álvarez de Toledo, Rafael I Barraquer, Sabine Kling   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure

Journal of Ophthalmology, 2019
Purpose. To investigate demographic and anatomical factors associated with a reduction in endothelial cell density (ECD) after phacoemulsification (PE) for the treatment of primary angle closure (PAC). Methods.
Carlo Alberto Cutolo, Chiara Bonzano, Carlo Catti, Alessandro Bagnis, Riccardo Scotto, Letizia Negri, Sara Olivari, Francesca Cappelli, Carlo Enrico Traverso   +8 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Correlation Between Anterior Chamber Volume and Corneal Biomechanical Properties in Human Eyes

Frontiers in Bioengineering and Biotechnology, 2019
Purpose: To investigate the correlation between anterior chamber volume (ACV) and corneal biomechanical properties in healthy and primary angle closure (PAC) eyes.Methods: A total of 79 eyes from 55 participants were enrolled in this study, including 24 ...
Xinhan Cui, Yujing Yang, Yue Li, Feifei Huang, Yujin Zhao, Huiyu Chen, Jianjiang Xu, Alireza Mashaghi, Jiaxu Hong, Jiaxu Hong, Jiaxu Hong, Jiaxu Hong   +11 more
doaj   +1 more source

Anterior segment parameters associated with extramuscular manifestations in polymyositis and dermatomyositis

International Journal of Ophthalmology, 2020
To evaluate detailed anterior segment parameters of patients with idiopathic inflammatory myopathies (IIM), including polymyositis (PM), and dermatomyositis (DM), and to clarify the associations between these data and clinical variables of IIM.Totally 57 PM, 41 DM patients and 62 controls were enrolled in this cross-sectional, observational, case ...
Zoltan Griger, Katalin Danko, Gabor Nemeth, Ziad Hassan, Zsuzsa Aszalos, Katalin Szabo, Levente Bodoki, Rudolf Gesztelyi, Judit Zsuga, Peter Szodoray, Adam Kemeny-Beke   +10 more
openaire   +3 more sources