Results 71 to 80 of about 872,875 (283)

"Between Structure and Incident. A Sociological-Institutionalist Approach to the Riddle of Transposition Delays of European Food Safety Directives" [PDF]

, 2005
[From the Introduction]. The Dutch cannot expand their highway system as they like, because that gets them in conflict with European air quality standards; strictly enforcing the latter could also deal a death blow to the huge Dutch chicken industry ...
Ieva Gange, Waarden, Frans van., Frans Van Waarden, Gange, Ieva   +3 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Graded recession with or without anterior transposition of the inferior oblique muscle for treatment of unilateral congenital superior oblique palsy

Journal of the Egyptian Ophthalmological Society, 2016
Purpose The aim of this study was to evaluate the efficacy of graded inferior oblique muscle recession (8–10 mm) and inferior oblique recession with anterior transposition (12 mm) in adult unilateral congenital superior oblique palsy patients with good ...
Rasha El Zeiny, Tharwat Mokbel, Hisham El Srougy, Hanem Kishk, Oliver Ehrt   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Performance and Return to Sport Following Ulnar Nerve Transposition/Decompression in Professional Baseball Players

Orthopaedic Journal of Sports Medicine, 2018
Background: Isolated ulnar nerve decompression/transposition is an uncommon surgery amongst professional baseball players. Purpose: To determine the rate of return to sport (RTS) and performance upon RTS in professional baseball players following ...
Brandon J. Erickson MD, Peter Nissen Chalmers MD, John D’Angelo, Kevin Ma, Anthony A. Romeo MD   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Dramatic neurologic recovery following humeral shaft ORIF with anterior transposition and primary radial nerve repair – Case report

Journal of Orthopaedic Reports
Background: Humeral shaft fractures are frequently complicated by radial nerve injuries, which often have poor prognosis despite surgical intervention. Early surgical repair and techniques to achieve tension-free nerve repair are critical for functional ...
Sohail Qazi, Jahan Aslami, John M. Rinaldi   +2 more
doaj   +1 more source

A novel technique for full thickness medial canthal reconstruction; playing with broken lines

Journal of Current Ophthalmology, 2016
Purpose: To introduce a new modification of transposition flap technique for reconstruction of the medial canthal region. Methods: This prospective study included 58 patients with the full thickness involvement of both upper and lower lid in the medial ...
Mohammad Taher Rajabi, Seyedeh Simindokht Hosseini, Mohammad Bagher Rajabi, Syed Ziaeddin Tabatabaie   +3 more
doaj   +1 more source

DNA-binding activity and subunit interaction of the mariner transposase [PDF]

, 2001
Mos1 is a member of the mariner/Tc1 family of transposable elements originally identified in Drosophila mauritiana. It has 28 bp terminal inverted repeats and like other elements of this type it transposes by a cut and paste mechanism, inserts at TA ...
Finnegan, D J, Dawson, A, Zhang, Lei
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source