Results 41 to 50 of about 961,624 (248)

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Wake Characteristics and Power Performance of a Drag-Driven in-Bank Vertical Axis Hydrokinetic Turbine

Energies, 2019
Preliminary design of a new installation concept of a drag-driven vertical axis hydrokinetic turbine is presented. The device consists of a three-bladed, wheel-shaped, turbine partially embedded in relatively shallow channel streambanks. It is envisioned
Jiyong Lee, Mirko Musa, Chris Feist, Jinjin Gao, Lian Shen, and Michele Guala   +5 more
doaj   +1 more source

A rare case of tularemic meningitis in the United States from aerosolized Francisella tularensis

Journal of the American College of Emergency Physicians Open, 2020
Tularemia is a rare zoonotic disease caused by Francisella tularensis. It can often present with varied clinical presentations, but meningitis is extremely rare.
Sriram Venkatesan, Christopher Johnston, Masoud Zarezadeh Mehrizi   +2 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Water Hyacinth (Eichornia Crassipes) Cellulose and Mung Beans (Viga Radiata) Starch as Composite Plant Bag with Plasticizer Glycerol

Journal of Education, Management and Development Studies
. Cellulose-starch blend was the remedy to the stark environmental issues of petrochemical-based plant bag (Technavio, 2019; Blick et al., 2014). Using the Randomized Complete Block Design, this study prompted to design a composite plant bag made of mung
Ronna Tataro- Samillano, Micka Mae Obis, Mark Oliva, Rheanne Osea   +3 more
doaj   +1 more source

AFRICA AND THE EXPANSION OF INTERNATIONAL SOCIETY: SURRENDERING THE SAVANNAH

Uluslararası Ekonomi, İşletme ve Politika Dergisi, 2021
Bu çalışmada 2015 yılında yayımlanmış John Anthony Pella,'ya ait "Africa and the Expansion of International Society: Surrendering the Savannah" adlı kitap incelenmiştir.
Murat Poyraz
doaj  

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Factors Associated With Uptake of Breast Cancer Screening Among Catholic Nuns in Lake Zone, Tanzania

International Journal of Breast Cancer
Conclusion: A study found a low uptake of breast cancer screening among Catholic nuns. This highlights the need for breast health intervention programs within religious congregations to address misconceptions and promote early detection.
Gotfrida Marandu, Rose Laisser, Kija Malale, Peter Rambau   +3 more
doaj   +1 more source

Multi-System Modeling Challenges for Integration of Parts for Increased Sustainability of Next Generation Aircraft

Engineering Proceedings
Innovative structures technologies can contribute to increasing the sustainability of next-generation aircraft. Advanced multi-disciplinary physics models, combined with data-based models, are needed to obtain optimized structures with maximum ...
Johan Kos, Marie Moghadasi, Tim Koenis, Bram Noordman, Ozan Erartsin, Ruben Nahuis   +5 more
doaj   +1 more source