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Anthracyclines and Mitochondria
2011Anthracyclines remain the cornerstone in the treatment of many malignancies including lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent chemotherapeutics is severely limited by the development of a progressive dose-dependent cardiomyopathy that irreversibly evolves toward congestive heart failure.
Mordente, Alvaro +4 more
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[Anthracycline cardiotoxicity].
La Clinica terapeutica, 2003To provide specialists and general practitioners with a review of the more recent data about anthracycline-induced cardiotoxicity and diagnostic methods utilized to reveal it.Reviewers identified studies concerning anthracycline cardiotoxicity, with special emphasis to those dealing with its pathogenesis and tools utilized for diagnosing it, by ...
FINOLEZZI E +3 more
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Cancer chemotherapy and biological response modifiers, 1990
After twenty years, understanding the mechanisms of tumor cells kill by anthracyclines still remains an active area of research. Of many mechanisms described for this class of drugs, efforts in the last year have focused on defining the role of free radical formation, topoisomerase II-induced DNA breakage, and P-170-dependent cellular accumulation of ...
B K, Sinha, P M, Politi
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After twenty years, understanding the mechanisms of tumor cells kill by anthracyclines still remains an active area of research. Of many mechanisms described for this class of drugs, efforts in the last year have focused on defining the role of free radical formation, topoisomerase II-induced DNA breakage, and P-170-dependent cellular accumulation of ...
B K, Sinha, P M, Politi
openaire +6 more sources
Cardiotoxicity of Anthracyclines
Cardiology ClinicsAnthracycline chemotherapy is associated with cardiotoxicity, predominantly manifesting as left ventricular systolic dysfunction within the first year of treatment. Early detection is possible through biomarkers and cardiovascular imaging before clinical symptoms develop.
Elizabeth, Balough +3 more
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Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming
Molecular Aspects of Medicine, 2023Andrea Ilari +2 more
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