Results 261 to 270 of about 150,779 (300)
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Inhibition of phospholipid methylation by an anti-allergic agent, NCO-650, during histamine release
Biochemical Pharmacology, 1990Antigen, anti-IgE and concanavalin A (Con A) induced an increase in both the incorporation of the 3H-methyl moiety into phospholipids and histamine release. Maximal incorporation of the 3H-methyl moiety into the lipid fraction of the cells was observed within 15 sec and 1 min after being challenged with antigen (100 micrograms/mL) and anti-IgE (200 ...
M, Takei +3 more
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International Archives of Allergy and Immunology, 1977
Sensitised bovine granulocytes release histamine when exposed to antigen. Several anti-allergic agents, some previously shown to be active in cattle, were tested to investigate their modulation of this histamine release process. Diethylcarbamazine citrate potentiated release at low concentrations and inhibited at high concentrations.
M C, Holroyde, P, Eyre
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Sensitised bovine granulocytes release histamine when exposed to antigen. Several anti-allergic agents, some previously shown to be active in cattle, were tested to investigate their modulation of this histamine release process. Diethylcarbamazine citrate potentiated release at low concentrations and inhibited at high concentrations.
M C, Holroyde, P, Eyre
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Inhibition of cAMP Increase by an Anti-Allergic Agent, NCO-650, during Histamine Release
International Archives of Allergy and Immunology, 1989Antigen and concanavalin A (Con A) induced an increase in cAMP and histamine release from rat peritoneal mast cells. In a dose-dependent manner, the compound, NCO-650, significantly inhibited both the initial and secondary increases in cAMP stimulated by antigen, anti-IgE and Con A in rat peritoneal mast cells. IC<sub>50</sub> values of NCO-
M, Takei +3 more
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Inhibition of Human Eosinophil Chemotaxis in Vitro by the Anti-Allergic Agent Emedastine Difumarate
Immunopharmacology and Immunotoxicology, 1996Emedastine difumarate (emedastine), an anti-allergic agent with anti-histaminic properties, was studied for its effect on human eosinophil chemotaxis induced by platelet activating factor (PAF). Peripheral blood eosinophils (98% purity) were obtained from healthy donors and chemotaxis assay were performed in microchemotaxis chambers.
A E, el-Shazly +4 more
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Medicinal Chemistry Research, 2015
DP antagonists are claimed to be useful in the treatment of allergic disorders. Laropiprant is a potent and selective DP antagonist to reduce the allergic disorders, especially niacin-induced flushing. In our study, a series of novel laropiprant derivatives (I-1–I-18) were synthesized and characterized by IR, 1H-NMR, 13C-NMR and HRMS spectrum.
Haiping Zhou +4 more
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DP antagonists are claimed to be useful in the treatment of allergic disorders. Laropiprant is a potent and selective DP antagonist to reduce the allergic disorders, especially niacin-induced flushing. In our study, a series of novel laropiprant derivatives (I-1–I-18) were synthesized and characterized by IR, 1H-NMR, 13C-NMR and HRMS spectrum.
Haiping Zhou +4 more
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[Anti-allergic properties of pipethiaden--a new preventive agent for migraine].
Ceskoslovenska farmacie, 1989Pipethiadene, a prophylactic of vasomotoric headaches of the series of 4,9-dihydrothieno(2,3-c)-2-benzothiepine derivatives, shows a peripheralpharmacological profile of an antiallergic agent. The experiments in rats showed a high antianaphylactic effect of pipethiadene in the passive cutaneous anaphylaxis (PCA) test.
H, Frycová, J, Metys
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Mast cell degranulation and its inhibition by an anti-allergic agent tranilast
Virchows Archiv B Cell Pathology, 1988Degranulation of IgE-sensitized rat mast cells by antigen was studied quantitatively in vitro and in vivo by electron microscopy. The inhibition of this degranulation by an anti-allergic drug, N-(3,4-dimethoxycinnamoyl)anthranilic acid (Tranilast), was also examined both in vitro and in vivo.
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Procaine as an anti-allergic agent.
Federation proceedings, 2008R H, DREISBACH, N, CHU
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