Perivascular mast cells regulate vein graft neointimal formation and remodeling [PDF]
PeerJ, 2015 Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft ...
Junxi Wu +9 more
doaj +6 more sources
Mast Cell Regulation of the Immune Response [PDF]
World Allergy Organization Journal, 2009 Mast cells are well known as principle effector cells of type I hypersensitivity responses. Beyond this role in allergic disease, these cells are now appreciated as playing an important role in many inflammatory conditions.
John J. Ryan, MD +4 more
doaj +3 more sources
The lectin ArtinM induces recruitment of rat mast cells from the bone marrow to the peritoneal cavity. [PDF]
PLoS ONE, 2010 BACKGROUND: The D-mannose binding lectin ArtinM is known to recruit neutrophils, to degranulate mast cells and may have potential therapeutic applications. However, the effect of ArtinM on mast cell recruitment has not been investigated.
Patricia Andressa de Almeida Buranello +5 more
doaj +1 more source
IgE Autoreactivity in Atopic Dermatitis: Paving the Road for Autoimmune Diseases?
Antibodies, 2020 Atopic dermatitis (AD) is a common skin disease affecting 20% of the population beginning usually before one year of age. It is associated with the emergence of allergen-specific IgE, but also with autoreactive IgE, whose function remain elusive.
Christophe Pellefigues
doaj +1 more source
Semaphorin-3 Promotes Specific Immunotherapy Effects on Experimental Food Allergy
Journal of Immunology Research, 2022 Sustaining higher frequency of mast cells in the allergic lesion site has been recognized. Factors causing high numbers of mast cells in the local tissues are not fully understood yet.
Huang Huang +11 more
doaj +1 more source
Current Gastroenterology Reports, 2010 Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity.
Terez, Shea-Donohue +3 more
openaire +2 more sources
Regulation of osteoclastogenesis by mast cell in rheumatoid arthritis
Arthritis Research & Therapy, 2021 Background In the pathogenesis of rheumatoid arthritis (RA), the role of mast cells has not been revealed clearly. We aimed to define the inflammatory and tissue-destructive roles of mast cells in rheumatoid arthritis (RA).
Kyoung-Woon Kim +6 more
doaj +1 more source
Mast Cells Express 11 beta-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation:a role in restraining mast cell degranulation [PDF]
, 2013 Mast cells are key initiators of allergic, anaphylactic and inflammatory reactions, producing mediators that affect vascular permeability, angiogenesis and fibrosis.
A Pesci +42 more
core +12 more sources
Mast cell-mediated immune regulation in health and disease
Frontiers in Medicine, 2023 Mast cells are important components of the immune system, and they perform pro-inflammatory as well as anti-inflammatory roles in the complex process of immune regulation in health and disease.
Kottarappat N. Dileepan +8 more
doaj +1 more source
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells
Stem Cell Reports, 2018 Summary: Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is
Mari-Liis Kauts +13 more
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