Results 1 to 10 of about 306,398 (210)
Perivascular mast cells regulate vein graft neointimal formation and remodeling [PDF]
PeerJ, 2015 Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graft ...
Junxi Wu +9 more
doaj +6 more sources
Mast Cell Activation Disorders [PDF]
Medicina, 2021 Background and Objectives: Mast cell disorders comprise a wide spectrum of syndromes caused by mast cells’ degranulation with acute or chronic clinical manifestations.
Arianna Giannetti +4 more
doaj +4 more sources
Mast cell activation within the mesentery depends on vagal signaling following abdominal surgery. [PDF]
Surg Open SciIntroduction: Abdominal surgery causes an inflammatory reaction in the intestines, resulting in a postoperative ileus. Mast cells can be divided into mucosal mast cells and connective tissue mast cells. In this study, we investigated mast cell activation
Woestemeier A +6 more
europepmc +2 more sources
Cardiovascular manifestations in mast cell activation disease: key insights for cardiologists and angiologists. [PDF]
Front Cardiovasc MedMast cell activation disease is a genetic disease entity characterized by a very pronounced clinical symptomatology with potential manifestations in virtually every organ and tissue.
Taumann W, Molderings GJ.
europepmc +2 more sources
Cells, 2022 Mast cells (MCs) function as a component of the tumor microenvironment (TME) and have both pro- and anti-tumorigenic roles depending on the tumor type and its developmental stage. Several reports indicate the involvement of MCs in angiogenesis in the TME
Irit Shefler +3 more
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Frontiers in Immunology, 2023 The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo.
Geethani Bandara +7 more
doaj +1 more source
Cells, 2021 Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD).
Magda Babina +3 more
doaj +1 more source
Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production
Haematologica, 2020 Persistent dysregulation of IL-6 production and signaling have been implicated in the pathology of various cancers. In systemic mastocytosis, increased serum levels of IL-6 associate with disease severity and progression, although the mechanisms involved
Araceli Tobío +9 more
doaj +1 more source
Current Gastroenterology Reports, 2010 Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity.
Terez, Shea-Donohue +3 more
openaire +2 more sources
Nature Communications, 2021 Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected ...
Do-Kyun Kim +9 more
doaj +1 more source