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Mast cells and canine mast cell tumours. A review [PDF]
Veterinary Quarterly, 2004 This article reviews the literature on mast cells and tumours derived from mast cells in the dog. Mast cells play a central role in inflammatory and immune reactions. Mast cells, normal and neoplastic, contain and release important biologically active substances: heparin, histamine, eosinophilic chemotactic factor and proteolytic enzymes.
exaly +3 more sources
Mast cell activation within the mesentery depends on vagal signaling following abdominal surgery [PDF]
Surgery Open ScienceIntroduction: Abdominal surgery causes an inflammatory reaction in the intestines, resulting in a postoperative ileus. Mast cells can be divided into mucosal mast cells and connective tissue mast cells. In this study, we investigated mast cell activation
Anna Woestemeier +6 more
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Mast cell specific Cyp11a1 deficiency promotes T cell mediated immunity and suppresses tumour metastasis in a mouse model of melanoma [PDF]
Scientific ReportsMast cells are emerging players in malignant conditions, but the underlying molecular mechanisms remain poorly defined. Based on previous studies showing that steroids can impact on tumour progression in various settings, we here investigated whether ...
Md. Abdul Alim, Katie Butcher
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Cells, 2022 Mast cells (MCs) function as a component of the tumor microenvironment (TME) and have both pro- and anti-tumorigenic roles depending on the tumor type and its developmental stage. Several reports indicate the involvement of MCs in angiogenesis in the TME
Irit Shefler +3 more
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Frontiers in Immunology, 2023 The HMC-1.2 human mast cell (huMC) line is often employed in the study of attributes of neoplastic huMCs as found in patients with mastocytosis and their sensitivity to interventional drugs in vitro and in vivo.
Geethani Bandara +7 more
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Cells, 2021 Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD).
Magda Babina +3 more
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Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production
Haematologica, 2020 Persistent dysregulation of IL-6 production and signaling have been implicated in the pathology of various cancers. In systemic mastocytosis, increased serum levels of IL-6 associate with disease severity and progression, although the mechanisms involved
Araceli Tobío +9 more
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Nature Communications, 2021 Osteoporosis and bone disease are common in patients with systemic mastocytosis. Here, the authors show that extracellular vesicles released by neoplastic mast cells of the patients block osteoblast differentiation and bone mineralization when injected ...
Do-Kyun Kim +9 more
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Current Gastroenterology Reports, 2010 Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity.
Terez, Shea-Donohue +3 more
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The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production. [PDF]
PLoS ONE, 2015 Current clinical and translational studies have shown that mast cell plays a pivotal role in multiple fibrotic diseases including scleroderma. However, the lack of mature human mast cell culture model exhibits a major obstacle for further dissection of ...
Gu Ningyan +4 more
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