Results 21 to 30 of about 5,434,736 (260)
Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome
International Journal of Infectious Diseases, 2020 Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2.
Lawrence B. Afrin +2 more
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Role of phosphoinositide 3-kinases in mast cell activation [PDF]
, 2009 Mast cells are primary effector cells in allergy and chronic inflammation. Class IB (PI3Kγ) and class IA (PI3Kδ) PI3K have been shown to play major roles in mast cell activation: antigen/IgE stimulation triggers autocrine/paracrine activation of mast ...
Collmann, Emilie
core +1 more source
Frontiers in Immunology, 2018 Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara +7 more
doaj +1 more source
MiR-146a: a key microRNA involved in regulating mast cell survival and T lymphocyte differentiation [PDF]
, 2013 Mast cells are long-lived, tissue-resident cells of the innate immune system. Since the identification of mechanisms that regulate mast cell proliferation, survival and overall homeostasis in the tissues may have important implications for the treatment ...
Rusca, Nicole-Lily
core +1 more source
Gastrointestinal Disorders, 2021 The aim was to assess methods utilized in assessing mast cell involvement in functional abdominal pain disorders (FAPDs), specifically to describe variability in methods utilized to assess both mast cell density and activation and determine if a ...
Hunter Friesen +4 more
doaj +1 more source
Frontiers in Immunology, 2021 Mast cell activators are a novel class of mucosal vaccine adjuvants. The polymeric compound, Compound 48/80 (C48/80), and cationic peptide, Mastoparan 7 (M7) are mast cell activators that provide adjuvant activity when administered by the nasal route ...
Brandi T. Johnson-Weaver +10 more
doaj +1 more source
Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells
Frontiers in Cell and Developmental Biology, 2021 Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions.
Sabrina Sofia Burgener +14 more
doaj +1 more source
Acta Veterinaria Scandinavica, 2022 Background Mast cell density has been shown to have both enhancing and inhibiting effects on tumour progression and the ability to predict breast cancer behaviour in humans. However, prognostic results have been contradictory.
Simona Sakalauskaitė +3 more
doaj +1 more source
Human placental extract suppresses mast cell activation and induces mast cell apoptosis
Allergy, Asthma & Clinical Immunology, 2023 Background Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been ...
Tongqian Wu +8 more
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Evaluation of Mast Cell Activation Syndromes: Impact of Pathology and Immunohistology [PDF]
, 2012 Mast cell activation syndromes (MCAS) are clinically defined disease states with a largely unknown morphological background. Since mastocytosis may be associated with MCAS, it is crucial in every patient to document or exclude mastocytosis by appropriate
Horny, H. -P., Valent, P., Sotlar, K.
core +1 more source