Results 21 to 30 of about 172,226 (310)

Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62 [PDF]

, 2013
ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc휀RI-mediated mast cell responses.
Dimity H. Ball, Al-Riyami, Lamyaa, Lamyaa Al-Riyami, Harnett, Margaret M., Harnett, Margaret, Ball, Dimity H., Michelle L. Coates, Kara S. Bell, Harnett, William, Bell, Kara S., Coates, Michelle L., Bell, Kara, Hwee Kee Tay, Ball, Dimity, Coates, Michelle, Rzepecka, Justyna, Margaret M. Harnett, Tay, Hwee Kee, Justyna Rzepecka, William Harnett   +19 more
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A Survey of Methodologies for Assessing Mast Cell Density and Activation in Patients with Functional Abdominal Pain Disorders

Gastrointestinal Disorders, 2021
The aim was to assess methods utilized in assessing mast cell involvement in functional abdominal pain disorders (FAPDs), specifically to describe variability in methods utilized to assess both mast cell density and activation and determine if a ...
Hunter Friesen, Meenal Singh, Vivekanand Singh, Jennifer V. Schurman, Craig A. Friesen   +4 more
doaj   +1 more source

PI3Kγ adapter subunits in mast cells [PDF]

, 2009
The incidence of allergy and related diseases such as asthma increased rapidly over the last century, especially in western societies. The allergic symptoms impair the quality of life of patients and can even be life threatening.
Bohnacker, Thomas
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Nasal Immunization With Small Molecule Mast Cell Activators Enhance Immunity to Co-Administered Subunit Immunogens

Frontiers in Immunology, 2021
Mast cell activators are a novel class of mucosal vaccine adjuvants. The polymeric compound, Compound 48/80 (C48/80), and cationic peptide, Mastoparan 7 (M7) are mast cell activators that provide adjuvant activity when administered by the nasal route ...
Brandi T. Johnson-Weaver, Hae Woong Choi, Hang Yang, Josh A. Granek, Cliburn Chan, Soman N. Abraham, Soman N. Abraham, Soman N. Abraham, Herman F. Staats, Herman F. Staats, Herman F. Staats   +10 more
doaj   +1 more source

Evaluation of Mast Cell Activation Syndromes: Impact of Pathology and Immunohistology [PDF]

, 2012
Mast cell activation syndromes (MCAS) are clinically defined disease states with a largely unknown morphological background. Since mastocytosis may be associated with MCAS, it is crucial in every patient to document or exclude mastocytosis by appropriate
Horny, H. -P., Valent, P., Sotlar, K.
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Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal [PDF]

, 2011
Activation of tissue mast cells (MCs) and their abnormal growth and accumulation in various organs are typically found in primary MC disorders also referred to as mastocytosis.
Triggiani, Massimo, Rudolf Valenta, Michel Arock, Arock, Michel, Philip Lieberman, Massimo Triggiani, Butterfield, Joseph H., Boguslaw Nedoszytko, Lawrence B. Schwartz, Dean D. Metcalfe, Alberto Orfao, Wolfgang R. Sperr, Valent, Peter, Brockow, Knut, Orfao, Alberto, Melody C. Carter, Karin Hartmann, Karl Sotlar, Schwartz, Lawrence B., Horny, Hans-Peter, Luis Escribano, Peter Valent, Cem Akin, Castells, Mariana, Escribano, Luis, Lieberman, Philip, Knut Brockow, Joseph H. Butterfield, Valenta, Rudolf, Hartmann, Karin, Metcalfe, Dean D., Hans-Peter Horny, Mariana Castells, Carter, Melody C., Sperr, Wolfgang R., Akin, Cem, Sotlar, Karl, Nedoszytko, Boguslaw   +37 more
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Association of mast cell density, microvascular density and endothelial area with clinicopathological parameters and prognosis in canine mammary gland carcinomas

Acta Veterinaria Scandinavica, 2022
Background Mast cell density has been shown to have both enhancing and inhibiting effects on tumour progression and the ability to predict breast cancer behaviour in humans. However, prognostic results have been contradictory.
Simona Sakalauskaitė, Vita Riškevičienė, Jakov Šengaut, Nomeda Juodžiukynienė   +3 more
doaj   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells [PDF]

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Hye Sun Kuehn, Gilfillan, Alasdair M., Michael A. Beaven, Alasdair M. Gilfillan, Kuehn, Hye Sun, Dean D. Metcalfe, Beaven, Michael A., Emily J. Swindle, Swindle, Emily J., Mi-Sun Kim, Kim, Mi-Sun, Metcalfe, Dean D.   +11 more
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The dark side of mast cells and their role in metastasis [PDF]

, 2014
Komarowska Marta Diana, Korakiewicz Gabriela, Pilaszewicz Agata, Hermanowicz Adam, Reszec Joanna, Debek Wojciech, Chyczewski Lech. The dark side of mast cells and their role in metastasis. Journal of Health Sciences. 2014;4(14):273-284. ISSN 1429-9623 /
Korakiewicz, Gabriela, Hermanowicz, Adam, Reszec, Joanna, Pilaszewicz, Agata, Debek, Wojciech, Chyczewski, Lech, Komarowska, Marta Diana   +6 more
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Non-canonical activation of PI3Kγ by Ca²⁺/PKCβ in mast cells [PDF]

, 2014
Mast cells are key effector cells in allergic disease triggering inflammation through mediator release. Allergens activate mast cells through the high-affinity receptor for IgE (FcεRI), which initiates signalling pathways that regulate the release of
Walser, Romy
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