Results 21 to 30 of about 12,201,289 (252)
Genome Biology, 2015 Single-cell transcriptomics reveals gene expression heterogeneity but suffers from stochastic dropout and characteristic bimodal expression distributions in which expression is either strongly non-zero or non-detectable.
Greg Finak +12 more
semanticscholar +1 more source
Frontiers in Immunology, 2018 Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentations
Geethani Bandara +7 more
doaj +1 more source
MiR-146a: a key microRNA involved in regulating mast cell survival and T lymphocyte differentiation [PDF]
, 2013 Mast cells are long-lived, tissue-resident cells of the innate immune system. Since the identification of mechanisms that regulate mast cell proliferation, survival and overall homeostasis in the tissues may have important implications for the treatment ...
Rusca, Nicole-Lily
core +1 more source
The mast cell and mast cell disease
Journal of the American Academy of Dermatology, 1995 Mast cell disease or mastocytosis is a heterogeneous group of clinical disorders characterized by the proliferation and accumulation of mast cells in a variety of tissues, most often the skin. The signs and symptoms of mast cell disease are varied, dependent on the localization of mast cells in different organs and the local and systemic effects of ...
J, Longley, T P, Duffy, S, Kohn
openaire +2 more sources
Mast cell subsets and their functional modulation by the Acanthocheilonema viteae product ES-62 [PDF]
, 2013 ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc휀RI-mediated mast cell responses.
Dimity H. Ball +19 more
core +1 more source
A Mast-Cell-Specific Receptor Mediates Neurogenic Inflammation and Pain.
Neuron, 2019 Mast cells can be found in close proximity to peripheral nerve endings where, upon activation, they release a broad range of pro-inflammatory cytokines and chemokines.
D. Green +4 more
semanticscholar +1 more source
PI3Kγ adapter subunits in mast cells [PDF]
, 2009 The incidence of allergy and related diseases such as asthma increased rapidly over the last century, especially in western societies. The allergic symptoms impair the quality of life of patients and can even be life threatening.
Bohnacker, Thomas
core +1 more source
Human placental extract suppresses mast cell activation and induces mast cell apoptosis
Allergy, Asthma & Clinical Immunology, 2023 Background Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been ...
Tongqian Wu +8 more
doaj +1 more source
Gastrointestinal Disorders, 2021 The aim was to assess methods utilized in assessing mast cell involvement in functional abdominal pain disorders (FAPDs), specifically to describe variability in methods utilized to assess both mast cell density and activation and determine if a ...
Hunter Friesen +4 more
doaj +1 more source