Results 11 to 20 of about 12,201,289 (252)

Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling [PDF]

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Background: Short-chain fatty acids (SCFAs) are fermented dietary components that regulate immune responses, promote colonic health, and suppress mast cell–mediated diseases.
Hendriks, Rudi, IJcken, W.F.J. (Wilfred) van, IJcken, Wilfred F. J. van, Hendriks, Rudi W., van den Berg, Mariska P.M., Bruijn, Marjolein J. W. de, Blokhuis, B, Folkerts, Gert, Ralph Stadhouders, Folkerts, Jelle, See‐Ying Tam, Tam, See‐Ying, Wilfred F. J. van IJcken, Junt, T. (Tobias), Marcus Maurer, Redegeld, F.A. (Frank), Hendriks, R.W. (Rudi), Tam, See-ying, Gert Folkerts, Berg, Mariska P. M. van den, Junt, Tobias, Hendriks, Rudi W, Maurer, Marcus, Maurer, M, van Ijcken, Wilfred, Junt, T, Folkerts, G. (Gert), Blokhuis, Bart, Van Den Berg, MP, Stadhouders, R. (Ralph), Redegeld, F, Redegeld, Frank, de Bruijn, M.J.W. (Marjolein J. W.), Blokhuis, B.R.J. (Bart), Jelle Folkerts, van IJcken, Wilfred F J, Galli, Stephen J, Tam, S.-Y. (See-Ying), van den Berg, M.P.M. (Mariska P. M.), van Ijcken, Wilfred; id_orcid, Galli, Stephen J., De Jong - de Bruijn, Marjolein, Folkerts, J. (Jelle), Rudi W. Hendriks, Mariska P. M. van den Berg, Marjolein J. W. de Bruijn, Bart Blokhuis, Tobias Junt, Folkerts, G, Galli, SJ, Wilfred F.J., van Ijcken, van den Berg, Mariska P M, Galli, S.J. (Stephen J.), Maurer, M. (Marcus), Frank Redegeld, de Bruijn, Marjolein J W, Marjolein J.W., de Bruijn, Tam, SY, Stadhouders, Ralph, Stephen J. Galli   +59 more
core   +2 more sources

Dnmt3a restrains mast cell inflammatory responses.

Proceedings of the National Academy of Sciences of the United States of America, 2017
DNA methylation and specifically the DNA methyltransferase enzyme DNMT3A are involved in the pathogenesis of a variety of hematological diseases and in regulating the function of immune cells.
Chiara Balestrieri, Sara Polletti, Balestrieri, Chiara, Bertoni, Francesco, Polletti, Sara, Monticelli, Silvia, Rinaldi, Andrea, Andrea Rinaldi, Montagner, Sara, Silvia Monticelli, Sara Montagner, Leoni, Cristina, Francesco Bertoni, Cristina Leoni   +13 more
core   +2 more sources

Mast-Cell-Derived TNF Amplifies CD8+ Dendritic Cell Functionality and CD8+ T Cell Priming

Cell Reports, 2015
Mast cells are critical promoters of adaptive immunity in the contact hypersensitivity model, but the mechanism of allergen sensitization is poorly understood.
Jan Dudeck, Shanawaz Mohammed Ghouse, Christian H.K. Lehmann, Anja Hoppe, Nadja Schubert, Sergei A. Nedospasov, Diana Dudziak, Anne Dudeck   +7 more
doaj   +2 more sources

Mast Cells [PDF]

Current Gastroenterology Reports, 2010
Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity.
Terez, Shea-Donohue, Jennifer, Stiltz, Aiping, Zhao, Luigi, Notari   +3 more
openaire   +2 more sources

The ingenious mast cell: Contemporary insights into mast cell behavior and function

Allergy. European Journal of Allergy and Clinical Immunology, 2020
Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood.
Joakim S. Dahlin, M. Maurer, D. Metcalfe, G. Pejler, R. Sagi-Eisenberg, G. Nilsson   +5 more
semanticscholar   +1 more source

The role of macrophage migration inhibitory factor in mast cell-stimulated fibroblast proliferation and collagen production. [PDF]

PLoS ONE, 2015
Current clinical and translational studies have shown that mast cell plays a pivotal role in multiple fibrotic diseases including scleroderma. However, the lack of mature human mast cell culture model exhibits a major obstacle for further dissection of ...
Gu Ningyan, Yao Xu, Shi Hongfei, Chen Jingjing, Chen Min   +4 more
doaj   +1 more source

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +1 more source

Adult-onset mast cell activation syndrome following scombroid poisoning: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Mast cells are closely associated with epithelium, serving as sentinels responsible for the recognition of tissue injury and coordination of the initial inflammatory response.
Isabelle Brock, Nicole Eng, Anne Maitland   +2 more
doaj   +1 more source

Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome

International Journal of Infectious Diseases, 2020
Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2.
Lawrence B. Afrin, Leonard B. Weinstock, Gerhard J. Molderings   +2 more
doaj   +1 more source

Role of phosphoinositide 3-kinases in mast cell activation [PDF]

, 2009
Mast cells are primary effector cells in allergy and chronic inflammation. Class IB (PI3Kγ) and class IA (PI3Kδ) PI3K have been shown to play major roles in mast cell activation: antigen/IgE stimulation triggers autocrine/paracrine activation of mast ...
Collmann, Emilie
core   +1 more source