Results 31 to 40 of about 306,398 (210)

Mast Cells: A New Frontier for Cancer Immunotherapy

Cells, 2021
Mast cells are unique tissue-resident immune cells of the myeloid lineage that have long been implicated in the pathogenesis of allergic and autoimmune disorders. More recently, mast cells have been recognized as key orchestrators of anti-tumor immunity,
Jake N. Lichterman, Sangeetha M. Reddy
doaj   +1 more source

Mast cell repopulation of the peritoneal cavity: contribution of mast cell progenitors versus bone marrow derived committed mast cell precursors

BMC Immunology, 2010
Background Mast cells have recently gained new importance as immunoregulatory cells that are involved in numerous pathological processes. One result of these processes is an increase in mast cell numbers at peripheral sites.
Pastor Maria, Campos Maria, Souza Júnior Devandir, Mello Luciana FC, Moreno Andréa N, Jamur Maria, Grodzki Ana, Silva Deise C, Oliver Constance   +8 more
doaj   +1 more source

The mast cell and mast cell disease

Journal of the American Academy of Dermatology, 1995
Mast cell disease or mastocytosis is a heterogeneous group of clinical disorders characterized by the proliferation and accumulation of mast cells in a variety of tissues, most often the skin. The signs and symptoms of mast cell disease are varied, dependent on the localization of mast cells in different organs and the local and systemic effects of ...
J, Longley, T P, Duffy, S, Kohn
openaire   +2 more sources

Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells

Cells, 2022
Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed.
Piper A. Robida, Clayton H. Rische, Netali Ben-Baruch Morgenstern, Rethavathi Janarthanam, Yun Cao, Rebecca A. Krier-Burris, Wouter Korver, Alan Xu, Thuy Luu, Julia Schanin, John Leung, Marc E. Rothenberg, Joshua B. Wechsler, Bradford A. Youngblood, Bruce S. Bochner, Jeremy A. O’Sullivan   +15 more
doaj   +1 more source

TH9 cells are required for tissue mast cell accumulation during allergic inflammation [PDF]

, 2015
BACKGROUND: IL-9 is important for the growth and survival of mast cells. IL-9 is produced by T cells, natural killer T cells, mast cells, eosinophils, and innate lymphoid cells, although the cells required for mast cell accumulation during allergic ...
Akhtar, Nahid, Glossen-Byers, Nicole L., Kaplan, Mark H., Nguyen, Evelyn T., Sehra, Sarita, Yao, Weiguo, Zhou, Baohua   +6 more
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Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: More than 90% of oral cancers are squamous cell carcinomas with oral leukoplakia being the most common potentially malignant disorder.
Saranya Ramsridhar, Malathi Narasimhan
doaj   +1 more source

Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is
Mari-Liis Kauts, Bianca De Leo, Carmen Rodríguez-Seoane, Roger Ronn, Fokion Glykofrydis, Antonio Maglitto, Polynikis Kaimakis, Margarita Basi, Helen Taylor, Lesley Forrester, Adam C. Wilkinson, Berthold Göttgens, Philippa Saunders, Elaine Dzierzak   +13 more
doaj   +1 more source

Choroidal mast cells in retinal pathology: a potential target for intervention. [PDF]

, 2015
Mast cells are important in the initiation of ocular inflammation, but the consequences of mast cell degranulation on ocular pathology remain uncharacterized.
Behar-Cohen, F., Bergin, C., Besson-Lescure, B., Bousquet, E., Castaneda, B., de Kozak, Y., Lorena, V., Naud, M.C., Thillaye-Goldenberg, B., Zhao, M.   +9 more
core   +1 more source

Induction of Mast Cell Accumulation by Tryptase via a Protease Activated Receptor-2 and ICAM-1 Dependent Mechanism

Mediators of Inflammation, 2016
Mast cells are primary effector cells of allergy, and recruitment of mast cells in involved tissue is one of the key events in allergic inflammation. Tryptase is the most abundant secretory product of mast cells, but little is known of its influence on ...
Xin Liu, Junling Wang, Huiyun Zhang, Mengmeng Zhan, Hanqiu Chen, Zeman Fang, Chiyan Xu, Huifang Chen, Shaoheng He   +8 more
doaj   +1 more source

Interactions between mast cells and smooth muscle in asthma models [PDF]

, 2014
Allergic asthma is the major phenotype of asthma and is characterized by specific responses to allergens as well as airway hyperresponsiveness (AHR), inflammation and remodelling.
Sjöberg, Lisa
core   +1 more source