Human cord blood derived immature basophils show dual characteristics, expressing both basophil and eosinophil associated proteins [PDF]
, 2012 Basophils are blood cells of low abundance associated with allergy, inflammation and parasite infections. To study the transcriptome of mature circulating basophils cells were purified from buffy coats by density gradient centrifugations and two-step ...
Grundström Jeanette +29 more
core +1 more source
Mast cell-neural interactions contribute to pain and itch
Immunological Reviews, 2018 Mast cells are best recognized for their role in allergy and anaphylaxis, but increasing evidence supports their role in neurogenic inflammation leading to pain and itch. Mast cells act as a “power house” by releasing algogenic and pruritogenic mediators,
K. Gupta, I. Harvima
semanticscholar +1 more source
Natural products AKTing on signal transduction pathways-molecules and methods [PDF]
, 2009 Natural products play an important role as source of inspiration for drug discovery and development and as tools for basic research. Isolated natural products that had shown diverse biological activity in previously published tests were analysed for ...
Kiefer, Sabine
core +1 more source
Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer
Journal of Immunological Research, 2018 Mast cells are unique tissue-resident immune cells that secrete a diverse array of biologically active compounds that can stimulate, modulate, or suppress the immune response.
Angélica Aponte-López +3 more
semanticscholar +1 more source
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells
Stem Cell Reports, 2018 Summary: Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is
Mari-Liis Kauts +13 more
doaj +1 more source
Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: More than 90% of oral cancers are squamous cell carcinomas with oral leukoplakia being the most common potentially malignant disorder.
Saranya Ramsridhar, Malathi Narasimhan
doaj +1 more source
Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]
, 2010 Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P. +5 more
core +1 more source
Mast Cell: A Multi-Functional Master Cell
Frontiers in Immunology, 2016 Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various ...
Melissa Krystel-Whittemore +2 more
semanticscholar +1 more source
Mast Cells and Their Progenitors in Allergic Asthma
Frontiers in Immunology, 2019 Mast cells and their mediators have been implicated in the pathogenesis of asthma and allergy for decades. Allergic asthma is a complex chronic lung disease in which several different immune cells, genetic factors and environmental exposures influence ...
Erika Méndez-Enríquez, Jenny Hallgren
doaj +1 more source
The role of mast cells in oral squamous cell carcinoma [PDF]
, 2017 The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue.
Raviteja Chitturi +5 more
core +1 more source