Regulation of mast cell function and survival in health and disease [PDF]
, 2016 Mast cells are sentinels of danger but they are also the major effector cells in allergic disease causing the well-known allergic symptoms caused by their mediators such as histamine and prostaglandin D2 that are released upon activation. Mastocytosis is
Lyberg, Katarina
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Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective [PDF]
International Neurourology Journal, 2015 Interleukin (IL) 33, a member of the IL-1 superfamily, is an “alarmin” protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders.
Tae Young Jang, Young Hyo Kim
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MODULATING THE INNATE IMMUNE RESPONSE TO ELECTROSPUN SCAFFOLDS AND POLYMER DEGRADATIVE BYPRODUCTS [PDF]
, 2017 Implanted biomaterials often induce inflammation that frequently leads to the foreign body response, fibrosis, and the failure of the implant. Thus, it is important to evaluate how cells interact with materials to promote a more regenerative response. It
Abebayehu, Daniel
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SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis [PDF]
, 2014 SHP2 protein-tyrosine phosphatase (encoded by Ptpn11) positively regulates KIT (CD117) signaling in mast cells and is required for mast cell survival and homeostasis in mice.
Craig, Andrew W.B. +4 more
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Stains Induce Apoptosis and Autophagy in Primary and Transformed Mast Cells [PDF]
, 2016 Statin drugs are widely employed in the clinic to reduce serum low density lipoproteins (LDLs) in patients with hypocholesteremia. In addition to their cholesterol-lowering effects through HMG CoA reductase antagonism, isoprenyl lipids necessary for ...
Paez, Patrick A
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Activation of the receptor KIT induces the secretion of exosome‐like small extracellular vesicles
Journal of Extracellular BiologyThe receptor tyrosine kinase (RTK) KIT and its ligand stem cell factor (SCF) are essential for human mast cell (huMC) survival and proliferation. HuMCs expressing oncogenic KIT variants secrete large numbers of extracellular vesicles (EVs).
Annika Pfeiffer +6 more
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Arf1 facilitates mast cell proliferation via the mTORC1 pathway
Scientific Reports, 2022 Mast cells are one of major players in allergic responses. Mast cell activation via the high affinity IgE receptor (FcεRI) causes degranulation and release of de novo synthesized proinflammatory cytokines in a process that involves vesicle trafficking ...
Yui Kotani +4 more
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Frontiers in Immunology, 2022 BackgroundImmunohistochemical analysis of granule-associated proteases has revealed that human lung mast cells constitute a heterogeneous population of cells, with distinct subpopulations identified.
Elin Rönnberg +18 more
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siRNA knockdown of SPHK1 in vivo protects mice from systemic, type-I Allergy. [PDF]
, 2007 Systemic anaphylaxis is considered to be a typical immediate hypersensitivity response, determined by the activation of immune cells, via antigen-induced aggregation of IgE-sensitized FcεRI cells.
Alirio Jose A. J. Melendez +2 more
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A transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers
OncoImmunology, 2017 To date, the exact impact of mast cells in tumor microenvironment is still controversial because of inconsistency in observations regarding the relationship between mast cell infiltrates and cancer development and prognosis. The discrepancies in previous
Eun-A Ko, Kenton M. Sanders, Tong Zhou
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