Results 71 to 80 of about 12,201,289 (252)

Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response.

PLoS ONE, 2019
BackgroundPrevious studies have revealed an important role for the transcription factor GATA-1 in mast cell maturation and degranulation. However, there have been conflicting reports with respect to the requirement of GATA-1 function in mast cell ...
Sribava Sharma, Sunil Tomar, Mayuri Dharne, Varsha Ganesan, Andrew Smith, Yanfen Yang, Lisa Waggoner, Yui-Hsi Wang, Simon P Hogan   +8 more
doaj   +1 more source

Arf1 facilitates mast cell proliferation via the mTORC1 pathway

Scientific Reports, 2022
Mast cells are one of major players in allergic responses. Mast cell activation via the high affinity IgE receptor (FcεRI) causes degranulation and release of de novo synthesized proinflammatory cytokines in a process that involves vesicle trafficking ...
Yui Kotani, Mami Sumiyoshi, Megumi Sasada, Toshio Watanabe, Satoshi Matsuda   +4 more
doaj   +1 more source

Suppressible and nonsuppressible autocrine mast cell tumors are distinguished by insertion of an endogenous retroviral element (IAP) into the interleukin 3 gene [PDF]

, 1993
After v-H-ras expression, the interleukin 3 (IL-3)-dependent PB-3c mast cells progress in vivo to two different classes of IL-3 autocrine tumors. Class I tumors show a germline configuration of the IL-3 gene and represent more than 90% of tumors analyzed
Nair, A. P., Hirsch, H. H., A P Nair, Moroni, C., C Moroni, H H Hirsch   +5 more
core   +1 more source

Cardiovascular manifestations in mast cell activation disease: key insights for cardiologists and angiologists

Frontiers in Cardiovascular Medicine
Mast cell activation disease is a genetic disease entity characterized by a very pronounced clinical symptomatology with potential manifestations in virtually every organ and tissue.
Wolfgang Taumann, Gerhard J. Molderings
doaj   +1 more source

Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist’s Perspective [PDF]

International Neurourology Journal, 2015
Interleukin (IL) 33, a member of the IL-1 superfamily, is an “alarmin” protein and is secreted in its active form from damaged cells undergoing necrotic cell death. Mast cells are one of the main effector cell types in allergic disorders.
Tae Young Jang, Young Hyo Kim
doaj   +1 more source

Immunoprofiling Reveals Novel Mast Cell Receptors and the Continuous Nature of Human Lung Mast Cell Heterogeneity

Frontiers in Immunology, 2022
BackgroundImmunohistochemical analysis of granule-associated proteases has revealed that human lung mast cells constitute a heterogeneous population of cells, with distinct subpopulations identified.
Elin Rönnberg, Elin Rönnberg, Daryl Zhong Hao Boey, Daryl Zhong Hao Boey, Avinash Ravindran, Avinash Ravindran, Jesper Säfholm, Jesper Säfholm, Ann-Charlotte Orre, Mamdoh Al-Ameri, Mikael Adner, Mikael Adner, Sven-Erik Dahlén, Sven-Erik Dahlén, Joakim S. Dahlin, Joakim S. Dahlin, Gunnar Nilsson, Gunnar Nilsson, Gunnar Nilsson   +18 more
doaj   +1 more source

The role of heparin in the activation of mast cell tryptase [PDF]

, 2004
Mast cells play an important role in our immune defense against bacteria and parasites but are also key effector cells in various inflammatory diseases. They act by releasing inflammatory mediators from intracellular granules.
Hallgren, Jenny
core  

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Hye Sun Kuehn, Gilfillan, Alasdair M., Michael A. Beaven, Alasdair M. Gilfillan, Kuehn, Hye Sun, Dean D. Metcalfe, Beaven, Michael A., Emily J. Swindle, Swindle, Emily J., Mi-Sun Kim, Kim, Mi-Sun, Metcalfe, Dean D.   +11 more
core   +1 more source

TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities [PDF]

, 2016
Dioxygenases of the TET family impact genome functions by converting 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC). Here, we identified TET2 as a crucial regulator of mast cell differentiation and proliferation.
Chiara Balestrieri, Balestrieri, Chiara, Ko, Myunggon, Gioacchino Natoli, Rao, Anjana, Iros Barozzi, Della Chiara, Giulia, Stefan Emming, Giulia Della Chiara, Montagner, Sara, Chiara, Della Giulia, Piccolo Viviana, Piccolo, Viviana, Susan Togher, Emming, Stefan, Monticelli, Silvia, Natoli, Gioacchino, Barozzi, Iros, Silvia Monticelli, Sara Montagner, Anjana Rao, Leoni, Cristina, Togher, Susan, Myunggon Ko, Viviana Piccolo, Cristina Leoni   +25 more
core   +1 more source

Release of Mast Cell Tryptase into Saliva: A Tool to Diagnose Food Allergy by a Mucosal Challenge Test? [PDF]

, 2011
Background: Our aim was to examine whether measurement of the saliva mast cell tryptase (MCT) concentrations before and after a mucosal challenge test with the offending food would be helpful in diagnosing food allergy.
Franziska Ruëff, Tanja Friedl, Matthias Kramer, Kramer, Matthias, Alexander Arnold, Rueff, Franziska, Arnold, Alexander, Przybilla, Bernhard, Bernhard Przybilla, Friedl, Tanja   +9 more
core   +1 more source