Results 91 to 100 of about 12,201,289 (252)
World Allergy Organization Journal, 2019 Background: Mast cells participate in immune responses by releasing potent immune system modifiers via degranulation. Due to currently reported controversial roles of mast cells in Streptococcus pneumoniae infections, this study aimed to determine the ...
Jing Yang +8 more
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Mast Cell Production and Response to IL-4 and IL-13
Cytokine, 2015 IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a prominent role in stimulating and maintaining the allergic response.
J. Mcleod, Bianca Baker, J. Ryan
semanticscholar +1 more source
Tetraspanins in Mast Cells [PDF]
Frontiers in Immunology, 2012 Mast cells (MC) are key mediators of the immune system, most prominently known for their role in eliciting harmful allergic reactions. Mast cell mediator release (e.g. by degranulation) is triggered by FcεRI recognition of antigen - IgE complexes. Until today no therapeutic targeting of this and other mast cell activation pathways is established. Among
Köberle, Martin +4 more
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Molecular Oncology, 2020 Mast cells are a major component of the immune microenvironment in tumour tissues and modulate tumour progression by releasing pro‐tumorigenic and antitumorigenic molecules.
Xuanwen Bao +3 more
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Mast Cell-Mediated Mechanisms of Nociception
International Journal of Molecular Sciences, 2015 Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense.
A. Aich, L. Afrin, K. Gupta
semanticscholar +1 more source
MiR-221 influences effector functions and actin cytoskeleton in mast cells. [PDF]
PLoS ONE, 2011 Mast cells have essential effector and immunoregulatory functions in IgE-associated allergic disorders and certain innate and adaptive immune responses, but the role of miRNAs in regulating mast cell functions is almost completely unexplored.
Ramon J Mayoral +6 more
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Mast cells and basophils [PDF]
Current Opinion in Hematology, 2000 Mast cells and basophils are effector cells in IgE-associated immune responses, such as those that contribute to asthma and other allergic diseases and to host resistance to parasites. Recent work shows that mast cells can also participate in innate immunity to bacterial infection and that the expression of such mast cell-dependent natural immunity can
openaire +2 more sources
Mast cell proteases as pharmacological targets
European Journal of Pharmacology, 2015 Mast cells are rich in proteases, which are the major proteins of intracellular granules and are released with histamine and heparin by activated cells. Most of these proteases are active in the granule as well outside of the mast cell when secreted, and
G. Caughey
semanticscholar +1 more source
Frontiers in Immunology, 2020 The thiol isomerase, protein disulfide isomerase (PDI), plays important intracellular roles during protein folding, maintaining cellular function and viability.
Dylan Krajewski +13 more
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, 2001 Chronic mast cell-mediated inflammation may contribute significantly towards the extensive tissue remodelling that is a feature of lungworm infection in ruminants.
C. J. Woodall +29 more
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