Results 91 to 100 of about 172,226 (310)

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Acidic pH is essential for maintaining mast cell secretory granule homeostasis [PDF]

, 2017
It has been recognized for a long time that the secretory granules of mast cells are acidic, but the functional importance of maintaining an acidic pH in the mast cell granules is not fully understood.
Sjöström, Daniel, Jun Mei Hu Frisk, Daniel Sjöström, Sveriges lantbruksuniversitet., Pejler, Gunnar,, Helena Öhrvik, Frisk, Jun Mei Hu,, Paivandy, Aida, Öhrvik, Helena, Pejler, Gunnar, Öhrvik, Helena,, Aida Paivandy, Frisk, Jun Mei Hu, Gunnar Pejler, Paivandy, Aida,   +14 more
core   +1 more source

Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling [PDF]

, 2020
Background: Short-chain fatty acids (SCFAs) are fermented dietary components that regulate immune responses, promote colonic health, and suppress mast cell–mediated diseases.
Hendriks, Rudi, IJcken, W.F.J. (Wilfred) van, IJcken, Wilfred F. J. van, Hendriks, Rudi W., van den Berg, Mariska P.M., Bruijn, Marjolein J. W. de, Blokhuis, B, Folkerts, Gert, Ralph Stadhouders, Folkerts, Jelle, See‐Ying Tam, Tam, See‐Ying, Wilfred F. J. van IJcken, Junt, T. (Tobias), Marcus Maurer, Redegeld, F.A. (Frank), Hendriks, R.W. (Rudi), Tam, See-ying, Gert Folkerts, Berg, Mariska P. M. van den, Junt, Tobias, Hendriks, Rudi W, Maurer, Marcus, Maurer, M, van Ijcken, Wilfred, Junt, T, Folkerts, G. (Gert), Blokhuis, Bart, Van Den Berg, MP, Stadhouders, R. (Ralph), Redegeld, F, Redegeld, Frank, de Bruijn, M.J.W. (Marjolein J. W.), Blokhuis, B.R.J. (Bart), Jelle Folkerts, van IJcken, Wilfred F J, Galli, Stephen J, Tam, S.-Y. (See-Ying), van den Berg, M.P.M. (Mariska P. M.), van Ijcken, Wilfred; id_orcid, Galli, Stephen J., De Jong - de Bruijn, Marjolein, Folkerts, J. (Jelle), Rudi W. Hendriks, Mariska P. M. van den Berg, Marjolein J. W. de Bruijn, Bart Blokhuis, Tobias Junt, Folkerts, G, Galli, SJ, Wilfred F.J., van Ijcken, van den Berg, Mariska P M, Galli, S.J. (Stephen J.), Maurer, M. (Marcus), Frank Redegeld, de Bruijn, Marjolein J W, Marjolein J.W., de Bruijn, Tam, SY, Stadhouders, Ralph, Stephen J. Galli   +59 more
core   +1 more source

Metformin: A potential adjunct for treatment of systemic mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Systemic mastocytosis (SM) is a clonal disorder of mast cells in which the KIT Asp816Val mutation can be detected not only in mature mast cells but also in the hematopoietic stem cell and in non–mast cell lineages.
Joseph H. Butterfield, MD, Kathleen Bartemes, PhD   +1 more
doaj   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Sodium Ascorbate‐Accelerated Gelling Hydrogels With Rapid Self‐Mineralized Capacity for Chronic Wounds

Advanced Science, EarlyView.
An immunoregulatory hydrogel based on sodium ascorbate (SA)‐accelerated gelation and in situ self‐mineralization is prepared here. Such a hydrogel is constructed by mixing benzaldehyde‐ and cyanoacetate‐functionalized dextran with silver nitrate (AgNO3) and SA, enabling the ultrafast solidification and in situ self‐mineralization of silver ...
Xiaoya Ding, Wei Yang, Wenzhao Li, Guifang Xu, Yuanjin Zhao   +4 more
wiley   +1 more source

Differential Gene Expression of Human Mast cell Activation Reveals Gene profiles of Innate and Adaptive Immunity. [PDF]

, 2007
High-density oligonucleotide microarray is a promising approach for high throughput analysis. It has been extensively used in many areas of biomedical research.
Alirio Jose Melendez, Reghunathan Renji, Peter Natesan Pushparaj, Jayapal J. Manikandan   +3 more
core   +2 more sources

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Role of Janus Kinase 3 in Mast Cell-Mediated Innate Immunity against Gram-Negative Bacteria [PDF]

, 2001
Mast cells play a pivotal role in innate host immune response to gram-negative bacteria. We report that Janus kinase 3 plays a role in mast cell-mediated bacterial clearance and neutrophil recruitment by regulating the release of tumor necrosis factor ...
Uckun, Fatih M, Malaviya, Ravi, Navara, Christopher   +2 more
core   +1 more source