Results 111 to 120 of about 5,434,736 (260)

Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study

, 2011
Mast cells reside in connective tissues and are widely recognized as effector cells important in innate and acquired immunity. These cells are the only ones capable of storing preformed TNF alpha in their cytoplasmatic granules and release upon ...
S. Teté, M.A. De Luths, G. Neri, P. Antinolfi, R. Galzio, G. Maccauro, M.L. Castellani, Y.B. Shaik-Dasthagirisaheb, Pandolfi, Franco, F. Conti, F. Pandolfi, A. Caraffa, E. Tomato, A. Anogeianaki, P. Felaco, T.C. Theoharides, M. Felaco, D. Tripodi, A. Saggini, M. Fulcheri   +19 more
core   +1 more source

Systemic mast cell disease (SMCD) [PDF]

, 1999
Review on Systemic mast cell disease (SMCD), with data on clinics, and the genes ...
Larizza, L, L. Larizza, A. Beghini, Beghini, A, A Beghini, L Larizza   +5 more
core   +1 more source

Mast cell activation within the mesentery depends on vagal signaling following abdominal surgery

Surgery Open Science
Introduction: Abdominal surgery causes an inflammatory reaction in the intestines, resulting in a postoperative ileus. Mast cells can be divided into mucosal mast cells and connective tissue mast cells. In this study, we investigated mast cell activation
Anna Woestemeier, Timo Schwandt, Philipp Lingohr, Mariola Lysson, Sven Wehner, Jörg C. Kalff, Gun-Soo Hong   +6 more
doaj   +1 more source

Metabolic‐Redox Remodeling of Inflammatory Synovium by Mannose‐Modified Selenium Nanoparticles for Osteoarthritis Therapy

Advanced Science, EarlyView.
Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou, Chen‐Hao Xu, Bo‐Wei Li, Leung Chan, Yi‐Di Xu, Han‐Bo Su, Rui Peng, Fang‐Ji Luo, Ya‐Chen Peng, Zhen‐Yan Li, Vincent Kam Wai Wong, Xiao‐Fei Zheng, Xing Ma, Zhen‐Gang Zha, Tianfeng Chen, Huan‐Tian Zhang   +15 more
wiley   +1 more source

The Role of Rho GTPases, Rac1 and Rac2, in Mast Cell Exocytosis

, 2012
Mast cells are tissue-resident immune cells that undergo exocytosis upon activation, releasing potent immunoregulatory molecules that initiate inflammatory responses.
Baier, Alicia
core   +1 more source

Evidence for dysbiosis in the gut microbiome of patients with systemic mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Limited research studies have investigated the role of the gut microbiome in systemic mastocytosis (SM), which is characterized by an aberrant expansion of clonal mast cells in specific tissues including the skin, marrow, liver, and the ...
Lauren E. Krausfeldt, PhD, Vivian Cao, MS, Richard Rodrigues, PhD, Wendy A. Henderson, PhD, Robin Eisch, RN, Linda M. Scott, LNP, Dean D. Metcalfe, MD, MS, Hirsh D. Komarow, MD   +7 more
doaj   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Relevância da formação de endotelina -1(1-31) na mediação do efeito nociceptivo da big endotelina-1 em camundongos: [dissertação] [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Farmacologia.The nociceptive effects of Endothelin-1 (ET) are well-known. This peptide is synthesized by cleavage of Big ET-1 by
Somensi, Amélia Regina
core  

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

Sub‐Second Ratiometric Fluorescence Imaging of Histamine Dynamics in Living Cells via a Supramolecular Probe

Advanced Science, EarlyView.
A tailored tripartite supramolecular ratiometric probe, engineered by modulating the fluorogenic guest's cationic locus, enables ultrafast histamine monitoring in living cells. Utilizing a competitive displacement mechanism, this system achieves a sub‐second response time with high selectivity.
Chenming Chan, Yujie Han, Yu‐Fei Song, Chunlei Jiang, Qi‐Wei Zhang   +4 more
wiley   +1 more source