Results 121 to 130 of about 5,434,736 (260)

Scoring of mast cell tumours.

, 2019
Scoring of mast cell tumours.
Lidia H. Pulz (5539790), Adriana T. Nishiya (5539799), Heidge Fukumasu (588307), Silvio Henrique de Freitas (6857948), Pamela A. Alexandre (6857939), Camila N. Barra (5539793), Karine G. Cadrobbi (6857945), Greice C. Huete (6857942), Ricardo F. Strefezzi (588312)   +8 more
core   +1 more source

Granzyme B from mast cells contributes to choroidal neovascularization in a model of wet age-related macular degeneration

Frontiers in Immunology
PurposeWet age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV), yet current anti-VEGF therapies are ineffective in many patients.
Manjosh Uppal, Amir Hosseini, Khola Bilal, Neilan Tan, Zhengyuan Ai, Wania Khan, Isa Samad, Gurmohit Gill, Hyung-Suk Yoo, Harshini Chakravarthy, Chuan-Hui Kuo, Jeanne Xi, David J. Granville, Joanne A. Matsubara   +13 more
doaj   +1 more source

SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo

Scientific Reports, 2017
Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation.
Hanna Pettersson, Behdad Zarnegar, Annika Westin, Viktor Persson, Christiane Peuckert, Jörgen Jonsson, Jenny Hallgren, Klas Kullander   +7 more
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer

, 2005
Purpose\ud The role played by the innate immune system in determining survival from non-small-cell lung cancer (NSCLC) is unclear. The aim of this study was to investigate the prognostic significance of macrophage and mast-cell infiltration in NSCLC ...
Waller, David A., Waller, David A, Green, Ruth H., Richardson, Donna, Welsh, Tomas J, O'Byrne, Kenneth J., Welsh, Tomas J., Green, Ruth H, Bradding, Peter, O'Byrne, Kenneth J   +9 more
core   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source

Acidic pH is essential for maintaining mast cell secretory granule homeostasis

, 2017
It has been recognized for a long time that the secretory granules of mast cells are acidic, but the functional importance of maintaining an acidic pH in the mast cell granules is not fully understood.
Sjöström, Daniel, Jun Mei Hu Frisk, Daniel Sjöström, Sveriges lantbruksuniversitet., Pejler, Gunnar,, Helena Öhrvik, Frisk, Jun Mei Hu,, Paivandy, Aida, Öhrvik, Helena, Pejler, Gunnar, Öhrvik, Helena,, Aida Paivandy, Frisk, Jun Mei Hu, Gunnar Pejler, Paivandy, Aida,, Sjöström, Daniel,   +15 more
core   +1 more source

An Explainable Multimodal Deep‐Learning Model Using Histopathological Image and Clinical Information for Prognosis Prediction in Colorectal Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study develops a multimodal deep‐learning model that integrates clinical variables and histopathological images to predict survival outcomes in colorectal cancer. The multimodal model effectively stratifies patients into low‐ and high‐risk groups, demonstrating superior accuracy and generalizability across multiple independent cohorts.
Zhihan Jiang, Xiangchao Shi, Chenghan Su, Yao Ma, Rui Li, Menglei Chen, Jianxin Cui, Nicholas Hawkins, Robyn Ward, Xiangzhi Bai, Jitendra Jonnagaddala, Wei Fu, Xin Zhou   +12 more
wiley   +1 more source

Mast Cell Proteoglycans

, 2012
Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease.
Melo, Fabio rabelo,, Sveriges lantbruksuniversitet., Pejler, Gunnar,, Rönnberg, Elin,   +3 more
core   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source