Results 121 to 130 of about 12,201,289 (252)

The Role of Rho GTPases, Rac1 and Rac2, in Mast Cell Exocytosis

, 2012
Mast cells are tissue-resident immune cells that undergo exocytosis upon activation, releasing potent immunoregulatory molecules that initiate inflammatory responses.
Baier, Alicia
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Mast cells and mastocytosis

Blood, 2008
AbstractMast cells have been recognized for well over 100 years. With time, human mast cells have been documented to originate from CD34+ cells, and have been implicated in host responses in both innate and acquired immunity. In clinical immunology, they are recognized for their central role in IgE-mediated degranulation and allergic inflammation by ...
openaire   +3 more sources

Regulation of Mast Cell Survival by IgE

, 2001
Mast cells play critical roles in hypersensitivity and in defense against certain parasites. We provide evidence that mouse mast cell survival and growth are promoted by monomeric IgE binding to its high-affinity receptor, FcϵRI.
Tsai, Mindy, Noboru Yamagata, Stephen J Galli, Liu, Fu-Tong, David P Carbone, Jiro Kitaura, Kawakami, Yuko, Toshiaki Kawakami, Yamagata, Noboru, Asai, Koichi, Kawakami, Toshiaki, Fu-Tong Liu, Koichi Asai, Kitaura, Jiro, Carbone, David P, Galli, Stephen J, Yuko Kawakami, Mindy Tsai   +17 more
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Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses [Elektronisk resurs]

, 2005
Bruton's tyrosine kinase (Btk) is thought to positively regulate mast cell activation, implying a role in allergic responses. We have compared acute and late phase allergic airway reactions in mice lacking either Btk or interleukin-2-inducible T cell ...
Erjefält, Jonas,, Forssell, J, Eriksson, C, Malm-Erjefält, Monika,, Sideras, Paschalis,, Ericsson, PO, Lund University., Rydell-Törmänen, Kristina,   +7 more
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Granzyme B from mast cells contributes to choroidal neovascularization in a model of wet age-related macular degeneration

Frontiers in Immunology
PurposeWet age-related macular degeneration (AMD) is characterized by choroidal neovascularization (CNV), yet current anti-VEGF therapies are ineffective in many patients.
Manjosh Uppal, Amir Hosseini, Khola Bilal, Neilan Tan, Zhengyuan Ai, Wania Khan, Isa Samad, Gurmohit Gill, Hyung-Suk Yoo, Harshini Chakravarthy, Chuan-Hui Kuo, Jeanne Xi, David J. Granville, Joanne A. Matsubara   +13 more
doaj   +1 more source

Immunological microenvironment in prostate cancer: high mast cell densities are associated with favorable tumor characteristics and good prognosis

, 2009
BACKGROUND: Number of intratumoral mast cells predicts survival in various cancers. The prognostic significance of such mast cells in surgically treated prostate cancer is unknown.
Achim Fleischmann, Martina Mirlacher, Huland, Hartwig, Erbersdobler, Andreas, Thorsten Schlomm, Hartwig Huland, Ronald Simon, Fleischmann, Achim, Guido Sauter, Sekulic, Nikolina, Andreas Erbersdobler, Schlomm, Thorsten, Sauter, Guido, Nikolina Sekulic, Köllermann, Jens, Mirlacher, Martina, Jens Köllermann, Simon, Ronald   +17 more
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The Mast Cell [PDF]

Journal of the Royal Society of Medicine, 1980
openaire   +2 more sources

Tumor Necrosis Factor-Alpha and Mast Cells: Revisited Study

, 2011
Mast cells reside in connective tissues and are widely recognized as effector cells important in innate and acquired immunity. These cells are the only ones capable of storing preformed TNF alpha in their cytoplasmatic granules and release upon ...
S. Teté, M.A. De Luths, G. Neri, P. Antinolfi, R. Galzio, G. Maccauro, M.L. Castellani, Y.B. Shaik-Dasthagirisaheb, Pandolfi, Franco, F. Conti, F. Pandolfi, A. Caraffa, E. Tomato, A. Anogeianaki, P. Felaco, T.C. Theoharides, M. Felaco, D. Tripodi, A. Saggini, M. Fulcheri   +19 more
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Mast cell stabilization promotes antinociceptive effects in a mouse model of postoperative pain

, 2013
Makoto Yasuda, Kanta Kido, Norimasa Ohtani, Eiji MasakiDepartment of Dental Anesthesiology and Pain Management, Tohoku University Hospital, Sendai, JapanBackground: Nerve injury and consequent inflammatory responses produced by surgical incision result ...
Yasuda M, Kido K, Masaki E, Ohtani N
core  

Mast cell heterogeneity

, 1984
Increasing evidence for the existence of inter- and intra-species mast cell heterogeneity has expanded the potential biological role of this cell. Early studies suggesting that mast cells at mucosal sites differ morphologically and histochemically from ...
A. D. Befus, J. A. Denburg, J. Bienenstock, F. Shanahan   +3 more
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