Results 101 to 110 of about 12,201,289 (252)

Mast Cells and Fibrinolysin [PDF]

Nature, 1961
DURING the investigation of human tissues for fibrinolytic activity the presence of a fibrinolytic substance was detected in a specimen of a spleen. This was a case of splenic mastocytosis previously reported1 in which there were many mast cells and a high concentration of histamine and heparin in the splenic tissue.
N, ENDE, J V, AUDITORE
openaire   +2 more sources

The STAT5-GATA2 Pathway Is Critical in Basophil and Mast Cell Differentiation and Maintenance

Journal of Immunology, 2015
Transcription factor GATA binding protein 2 (GATA2) plays critical roles in hematopoietic stem cell survival and proliferation, granulocyte–monocyte progenitor differentiation, and basophil and mast cell differentiation.
Yapeng Li, Xiaopeng Qi, Bing Liu, Hua Huang   +3 more
semanticscholar   +1 more source

The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis

BioMed Research International, 2015
An association between mast cells and tumor angiogenesis is known to exist, but the exact role that mast cells play in this process is still unclear. It is thought that the mediators released by mast cells are important in neovascularization. However, it
D. A. de Souza Júnior, Ana Carolina Santana, E. Z. M. da Silva, C. Oliver, M. Jamur   +4 more
semanticscholar   +1 more source

Metformin: A potential adjunct for treatment of systemic mastocytosis

Journal of Allergy and Clinical Immunology: Global
Background: Systemic mastocytosis (SM) is a clonal disorder of mast cells in which the KIT Asp816Val mutation can be detected not only in mature mast cells but also in the hematopoietic stem cell and in non–mast cell lineages.
Joseph H. Butterfield, MD, Kathleen Bartemes, PhD   +1 more
doaj   +1 more source

Mast Cell Function

Journal of Histochemistry and Cytochemistry, 2014
Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as effectors of allergy. It has been only in the past two decades that mast cells have gained recognition for their involvement in other physiological and pathological ...
E. Z. M. da Silva, M. Jamur, C. Oliver
semanticscholar   +1 more source

No role for mast cells in obesity-related metabolic dysregulation

Frontiers in Immunology, 2016
Obesity-related adipose tissue (AT) inflammation that promotes metabolic dysregulation is associated with increased AT mast cell numbers. Mast cells are potent inducers of inflammatory responses and could potentially contribute to obesity-induced AT ...
Jindřich Chmelař, Jindřich Chmelař, Antonios Chatzigeorgiou, Antonios Chatzigeorgiou, Kyoung-jin Chung, Kyoung-jin Chung, Kyoung-jin Chung, Marta Prucnal, David Voehringer, Axel Roers, Triantafyllos Chavakis, Triantafyllos Chavakis, Triantafyllos Chavakis, Triantafyllos Chavakis   +13 more
doaj   +1 more source

Highly Aggressive CD4-Positive Mast Cell Leukaemia (Leukaemic Variant) Associated with Isolated Trisomy 19 and Hemophagocytosis by Neoplastic Mast Cells: A Case Report with Challenging Experience and Review

Case Reports in Hematology, 2019
Background. Mast cell leukaemia is a unique disease among hematopoietic neoplasms, being one of the rarest leukaemia subtypes. In addition, its prompt diagnosis is usually challenging.
Dina Sameh Soliman, Ahmad Al-Sabbagh, Feryal Ibrahim, Amna Gameil, Mohamed Yassin, Halima El-Omri   +5 more
doaj   +1 more source

Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation[S]

Journal of Lipid Research, 2013
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, accumulates in the atherosclerotic plaque. It has the capacity to activate mast cells, which potentially exacerbates plaque progression.
Martine Bot, Saskia C.A. de Jager, Luke MacAleese, H. Maxime Lagraauw, Theo J.C. van Berkel, Paul H.A. Quax, Johan Kuiper, Ron M.A. Heeren, Erik A.L. Biessen, Ilze Bot   +9 more
doaj   +1 more source

Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness

JCI Insight, 2021
Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease.
Xiaomei Kong, William C. Bennett, Corey M. Jania, Kelly D. Chason, Zachary German, Jennifer Adouli, Samuel D. Budney, Brandon T. Oby, Catharina van Heusden, Eduardo R. Lazarowski, Ilona Jaspers, Scott H. Randell, Barry A. Hedgespeth, Glenn Cruse, Xiaoyang Hua, Stephen A. Schworer, Gregory J. Smith, Samir N.P. Kelada, Stephen L. Tilley   +18 more
doaj   +1 more source

Transcription Factor GATA1 Is Dispensable for Mast Cell Differentiation in Adult Mice

, 2014
Although previous studies have shown that GATA1 is required for mast cell differentiation, the effects of the complete ablation of GATA1 in mast cells have not been examined.
Yamamoto, M, Ohneda, K, Philipsen, Sjaak, Satoh, H, Moriguchi, T, Ishijima, Y, Ohmori, S   +6 more
core   +1 more source