Identification of a mast cell specific receptor crucial for pseudo-allergic drug reactions
Nature, 2014 Mast cells are primary effectors in allergic reactions, and may have important roles in disease by secreting histamine and various inflammatory and immunomodulatory substances. Although they are classically activated by immunoglobulin (Ig)E antibodies, a
Benjamin D. McNeil +6 more
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Activation of the receptor KIT induces the secretion of exosome‐like small extracellular vesicles
Journal of Extracellular BiologyThe receptor tyrosine kinase (RTK) KIT and its ligand stem cell factor (SCF) are essential for human mast cell (huMC) survival and proliferation. HuMCs expressing oncogenic KIT variants secrete large numbers of extracellular vesicles (EVs).
Annika Pfeiffer +6 more
doaj +1 more source
A transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers
OncoImmunology, 2017 To date, the exact impact of mast cells in tumor microenvironment is still controversial because of inconsistency in observations regarding the relationship between mast cell infiltrates and cancer development and prognosis. The discrepancies in previous
Eun-A Ko, Kenton M. Sanders, Tong Zhou
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Rat embryonic mast cells originate in the AGM. [PDF]
PLoS ONE, 2013 Mast cells originate from pluripotent hematopoietic stem cells. Two mast cell specific antibodies, mAbsAA4 and BGD6, have previously been used to identify and study committed mast cell precursors (MCcps) in the bone marrow of adult mice and rats. However,
Michel Farchi Guiraldelli +7 more
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Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]
, 2013 Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
Kathrin Rothe (386395) +23 more
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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012 Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their involvement in acquired and innate immunity. Increasing evidence now implicates mast cells in inflammatory diseases where they are activated by non-allergic triggers, such as neuropeptides and cytokines, often exerting synergistic effects as in the case of
Theoharides, Theoharis C. +10 more
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Cellular Energetics of Mast Cell Development and Activation
Cells, 2021 Mast cells are essential first responder granulocytes in the innate immune system that are well known for their role in type 1 immune hypersensitivity reactions.
Ryan P. Mendoza +2 more
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Effect of dietary fiber and metabolites on mast cell activation and mast cell-associated diseases [PDF]
, 2018 Many mast cell-associated diseases, including allergies and asthma, have seen a strong increase in prevalence during the past decades, especially in Western(ized) countries.
Hendriks, Rudi +31 more
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, 2016 Mast cell tumor is one of the major cutaneous tumors in dogs. Though the etiology of MCTs is not completely understood, it becomes clear that approximately 10–20% MCTs express mutant KIT receptors with ligand‐independent phosphorylation.
Y. Amagai, A. Tanaka
semanticscholar +1 more source
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells.
Cell, 2021 Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the similarity and distinction of their fundamental properties across different tumors remain elusive.
Si Cheng +19 more
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