Results 1 to 10 of about 87,250 (304)

Purified Compounds from Phyllanthus amarus Schum. & Thonn. Inhibit Mast Cell Degranulation via Modulation of Syk/PLCγ Signaling [PDF]

Molecules
Phyllanthus amarus has long been used in traditional medicine and contains diverse bioactive compounds with potential pharmacological properties. This study aimed to purify the compounds from P.
Thanh Sang Vo, Vo Thi Ngoc My, Phan Van Hoai Luan, Dai-Hung Ngo   +3 more
doaj   +2 more sources

Key Players and Pathways of Mast Cell Activation in Urticaria [PDF]

Journal of Inflammation Research
Carolin Jahn,1,2 Dimitra Gialama,1,2 Margarita Pashuk,1– 3 Yi-Kui Xiang,1,2,* Pavel Kolkhir1,2,*1Insitiute of Allergology, Charité – University Medical Center Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität ...
Jahn C, Gialama D, Pashuk M, Xiang YK, Kolkhir P   +4 more
doaj   +2 more sources

The Suppressive Activity of Fucofuroeckol-A Derived From Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation

Marine Drugs, 2018
UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its ...
BoMi Ryu, Se-Kwon Kim, Long Giang Bach
exaly   +3 more sources

Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs

Frontiers in Pharmacology, 2021
Neutrophilic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), or psoriasis, exert a huge burden on the global health system due to the lack of safe and effective treatments. Volatile
Michal Korinek, Michal Korinek, Michal Korinek, Heba Handoussa, Yi-Hong Tsai, You-Ying Chen, Meng-Hua Chen, Zan-Wei Chiou, Yu Fang, Fang-Rong Chang, Chia-Hung Yen, Chung-Fan Hsieh, Bing-Hung Chen, Mohamed El-Shazly, Mohamed El-Shazly, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang   +18 more
doaj   +1 more source

Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses

Frontiers in Immunology, 2022
Host defense against bacterial and fungal infections diminishes with age. In humans, impaired neutrophil responses are thought to contribute to this decline. However, it remains unclear whether neutrophil responses are also impaired in old mice. Here, we
Kirsti Hornigold, Julia Y. Chu, Stephen A. Chetwynd, Polly A. Machin, Laraine Crossland, Chiara Pantarelli, Karen E. Anderson, Phillip T. Hawkins, Anne Segonds-Pichon, David Oxley, Heidi C. E. Welch   +10 more
doaj   +1 more source

Mast cell distribution around the needle tract following acupuncture in Zusanli (ST36) acupoint in rats [PDF]

Bulgarian Journal of Veterinary Medicine, 2019
The aim of this study was to investigate mast cell (MCs) distribution in the vicinity of the needle tract formed after acupuncture in Zusanli (ST36) acupoint in rats.
N. D. Dimitrov, D. Y. Atanasova, N. S. Tomov, Y. A. Staykova-Pirovska, I. G. Ivanova , D. P. Sivrev   +5 more
doaj   +1 more source

Differential Regulation of Granule Release in Platelets and Immune Cells [PDF]

TH Open
Qing Xia, Jiandao Hu, Hongcun Sun, Zhixiang Zhu, Wenbo Jiang   +4 more
doaj   +2 more sources

Myeloid-Specific Pyruvate-Kinase-Type-M2-Deficient Mice Are Resistant to Acute Lung Injury

Biomedicines, 2022
Infiltration of polymorphonuclear neutrophils (PMNs) plays a central role in acute lung injury (ALI). The mechanisms governing PMN inflammatory responses, however, remain incompletely understood.
Xinlei Sun, Fujie Shi, Weiran Wang, Yunfei Wu, Shuang Qu, Jing Li, Hongwei Liang, Ke Zen   +7 more
doaj   +1 more source

Locked and Loaded: Mechanisms Regulating Natural Killer Cell Lytic Granule Biogenesis and Release

Frontiers in Immunology, 2022
NK cell-mediated cytotoxicity is a critical element of our immune system required for protection from microbial infections and cancer. NK cells bind to and eliminate infected or cancerous cells via direct secretion of cytotoxic molecules toward the bound
Hyoungjun Ham, Michael Medlyn, Daniel D. Billadeau, Daniel D. Billadeau   +3 more
doaj   +1 more source

Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria

Frontiers in Immunology, 2021
Mast cell-activating signals in cold urticaria are not yet well defined and are likely to be heterogeneous. Cold agglutinins and cryoglobulins have been described as factors possibly associated with cold urticaria, but their relevance has not been ...
Mojca Bizjak, Mitja Košnik, Dorothea Terhorst-Molawi, Dejan Dinevski, Marcus Maurer   +4 more
doaj   +1 more source