Results 11 to 20 of about 87,250 (304)
Mechanisms of Degranulation in Neutrophils [PDF]
Allergy, Asthma & Clinical Immunology, 2006 AbstractNeutrophils are critical inflammatory cells that cause tissue damage in a range of diseases and disorders. Being bone marrow-derived white blood cells, they migrate from the bloodstream to sites of tissue inflammation in response to chemotactic signals and induce inflammation by undergoing receptor-mediated respiratory burst and degranulation ...
Lacy Paige, Paige Lacy
openaire +5 more sources
SAT1-Induced Spermidine Depletion Potentiates Food Allergy. [PDF]
Adv Sci (Weinh)Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Liu M +8 more
europepmc +2 more sources
Mechanisms of Eosinophil Degranulation. [PDF]
CellsEosinophils are highly granulated white blood and tissue cells that play complex roles in the immune system including host protection against helminthic parasites, viruses, fungi, and bacteria. These bone marrow-derived cells cause tissue damage in a range of diseases and disorders, particularly in allergy, asthma, and chronic rhinosinusitis with nasal
Almas S, Lacy P.
europepmc +4 more sources
Degranulation deconstructed [PDF]
Journal of Clinical Investigation, 2012 Pediatricians first described the clinical features of chronic granulomatous disease (CGD) in 1959. Almost a decade later, in a collaborative effort that crossed disciplines, we participated in the discoveries that defined the cellular deficiencies of CGD, specifically finding that improper degranulation of leukocytes did not explain their failure to ...
Robert L, Baehner, Morris J, Karnovsky
openaire +2 more sources
Molecules, 2022 Atopic dermatitis (AD) is a chronic inflammatory dermal disease with symptoms that include inflammation, itching, and dry skin. 1-Iodohexadecane is known as a component of Chrysanthemum boreale essential oil that has an inhibitory effect on AD-like ...
Do Yoon Kim +5 more
doaj +1 more source
Myeloperoxidase: Regulation of Neutrophil Function and Target for Therapy
Antioxidants, 2022 Neutrophils, the most abundant white blood cells in humans, are critical for host defense against invading pathogens. Equipped with an array of antimicrobial molecules, neutrophils can eradicate bacteria and clear debris.
Salma A. Rizo-Téllez +2 more
doaj +1 more source
DOCK2 Mutation and Recurrent Hemophagocytic Lymphohistiocytosis
Life, 2023 Hemophagocytic lymphohistiocytosis (HLH) is a syndrome resulting from uncontrolled hyper-inflammation, excessive immune system activation, and elevated levels of inflammatory cytokines.
Daniel D. Reiff +2 more
doaj +1 more source
Degranulation response in cytotoxic rat lymphocytes measured with a novel CD107a antibody
Frontiers in Immunology, 2016 Measuring degranulation through CD107a expression has become an advantageous tool for testing the functional capacity of cytotoxic cells. Such functional studies have been hampered in the rat by the lack of a suitable anti-rat CD107a antibody.
Amanda Sudworth +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive ...
Jia Li +10 more
doaj +1 more source
Pharmacology Research & Perspectives, 2020 Acute respiratory virus infections, such as influenza and RSV, are predominant causes of asthma exacerbations. Eosinophils act as a double‐edged sword in exacerbations in that they are activated by viral infections but also can capture and inactivate ...
Yanaika Shari Sabogal Piñeros +8 more
doaj +1 more source