Results 41 to 50 of about 87,250 (304)

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Evaluation of the Therapeutic Effectiveness of Combined Action Antiallergic Drugs in Monotherapy of Allergic Conjunctivitis

Oftalʹmologiâ, 2020
According to statistical studies in recent decades, there has been an increase of allergic diseases in most countries of the world. Predisposing factors are the deterioration of the environmental situation, the total “chemicalization” of life and the ...
N. G. Zumbulidze, V. M. Khokkanen, I. B. Litvin   +2 more
doaj   +1 more source

Degranulation (% release, median (IQR)).

, 2019
Degranulation (% release, median (IQR)).
Lisa Holm (6858143), Sophie Ohlsson (516282), Christina Hansson (6858146), Lena Gunnarsson (330558), Lillemor Skattum (836044), Susanne M. Ohlsson (6858149), Åsa Pettersson (330556)   +6 more
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Patient characteristics/ degranulation PMNs.

, 2015
Patient characteristics/ degranulation PMNs.
Marc Dresel (687824), Severin Schmid (340111), Bernd Schmeck (334625), Timm Greulich (340109), Claus Franz Vogelmeier (687826), Sabina Janciauskiene (264288), Andreas Rembert Koczulla (340119), Janine Koepke (687823), Björn Beutel (687825)   +8 more
core   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

ANTIMICROBIC MECHANISMS OF NEUTROPHILES AS PERSPECTIVE TARGETS FOR PHARMACOLOGICAL MODULATION OF NON-SPECIFIC PROTECTION OF THE ORGANISM

Журнал микробиологии, эпидемиологии и иммунобиологии, 2019
Key roles in nonspecific protection of the macroorganism are played by neutrophils — the most numerous pool of leukocytes. During the development of infection these cells phagocytose of microorganisms and also secrete proteolytic enzymes that destroy ...
E. V. Matosova, B. G. Andryukov
doaj   +1 more source

Degranulation controls (% release, median (IQR)).

, 2019
Degranulation controls (% release, median (IQR)).
Lisa Holm (6858143), Sophie Ohlsson (516282), Christina Hansson (6858146), Lena Gunnarsson (330558), Lillemor Skattum (836044), Susanne M. Ohlsson (6858149), Åsa Pettersson (330556)   +6 more
core   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

Study on γδT-Cell Degranulation at Maternal–Fetal Interface via iKIR–HLA-C Axis

Cells
Maternal–fetal tolerance mechanisms are crucial during human pregnancy to prevent the immune rejection of the embryo. A well-known mechanism blocking NK-cell cytotoxicity is the interaction of their inhibitory killer-cell immunoglobulin-like receptors ...
Diana Manchorova, Marina Alexandrova, Antonia Terzieva, Ivaylo Vangelov, Ljubomir Djerov, Iana Hristova, Gil Mor, Tanya Dimova   +7 more
doaj   +1 more source