Results 61 to 70 of about 87,250 (304)

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Sub‐Second Ratiometric Fluorescence Imaging of Histamine Dynamics in Living Cells via a Supramolecular Probe

Advanced Science, EarlyView.
A tailored tripartite supramolecular ratiometric probe, engineered by modulating the fluorogenic guest's cationic locus, enables ultrafast histamine monitoring in living cells. Utilizing a competitive displacement mechanism, this system achieves a sub‐second response time with high selectivity.
Chenming Chan, Yujie Han, Yu‐Fei Song, Chunlei Jiang, Qi‐Wei Zhang   +4 more
wiley   +1 more source

Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis

Frontiers in Immunology, 2020
Studies have endeavored to understand the cause for impaired antimicrobial killing by neutrophils of people with cystic fibrosis (PWCF). The aim of this study was to focus on the bacterial phagosome.
Elaine Hayes, Mark P. Murphy, Kerstin Pohl, Niall Browne, Karen McQuillan, Le Er Saw, Clare Foley, Fatma Gargoum, Oliver J. McElvaney, Padraig Hawkins, Cedric Gunaratnam, Noel G. McElvaney, Emer P. Reeves   +12 more
doaj   +1 more source

Fluoride prevents degranulation of the azurophilic and specific granules in electropermeabilized neutrophils

, 1994
The effect of A1F4- on the degranulation process in human neutrophils was investigated. In intact neutrophils, A1F4- induced degranulation, whereas in electropermeabilized neutrophils A1F4- did not stimulate degranulation.
G C Roger Kessels, Hans W M Niessen, Arthur J Verhoeven   +2 more
core   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source

Degranulation and cytokine secretion of NK-cells.

, 2014
MNCs were incubated for 6 hours with and without K562 cells at +37°C and the degranulation (CD107a/b expression) and cytokine secretion of NK-cells was measured by flow cytometry.
Teresa Melo (517725), Satu Mustjoki (210642), Mette Ilander (208591), Edgar Faber (210615), Jukka Vakkila (210636), Kimmo Porkka (210641), Peter Rohon (210611), Anna Kreutzman (210606)   +7 more
core   +1 more source

Natural products AKTing on signal transduction pathways-molecules and methods [PDF]

, 2009
Natural products play an important role as source of inspiration for drug discovery and development and as tools for basic research. Isolated natural products that had shown diverse biological activity in previously published tests were analysed for ...
Kiefer, Sabine
core   +1 more source

Indole‐3‐Acetic Acid Protects Bovine Hepatocytes Against Palmitic Acid‐Induced Lipid Accumulation and ER Stress Through SIRT3

Animal Research and One Health, EarlyView.
Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi, Chenchen Zhao, Guiying Li, Jinxia Li, Menglin Liu, Fanrong Kong, Enzhu Li, Jie Gao, Wenqi Liao, Akos Kenez, Wenwen Gao, Yuxiang Song, Xiliang Du, Guowen Liu, Xinwei Li, Lin Lei   +15 more
wiley   +1 more source

Neutrophils in Psoriasis

Frontiers in Immunology, 2019
Neutrophils are the most abundant innate immune cells. The pathogenic roles of neutrophils are related to chronic inflammation and autoimmune diseases. Psoriasis is a chronic systemic inflammatory disease affecting ~2–3% of the world population.
Chih-Chao Chiang, Chih-Chao Chiang, Chih-Chao Chiang, Wei-Jen Cheng, Wei-Jen Cheng, Wei-Jen Cheng, Michal Korinek, Michal Korinek, Michal Korinek, Cheng-Yu Lin, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang   +15 more
doaj   +1 more source

Histone H1-mediated mast cell degranulation.

, 2016
(A) Exogenous histone H1 dose-dependently induced degranulation of IgE-sensitized rat basophilic leukemia cell line RBL-2H3 without cross-linking between anti-DNP-IgE and antigen (Ag: DNP-BSA). Degranulation was evaluated by β-hexosaminidase release rate.
Yayoi Shimada (2614654), Yuki Takaoka (2614657), Naoya Ohmori (2614651), Seiji Kawamoto (322967), Chia-Yun Lai (322960), Chao-Long Chen (322349), Kuei-Chen Chiang (2614663), Takashi Fujimura (2335291), Takeshi Goto (2614648), Shigeru Goto (322962), Ayane Hori (2614660), Rikiya Kamei (2614666), Toshiaki Nakano (27092), Kazuhisa Ono (322970)   +13 more
core   +1 more source