Results 51 to 60 of about 87,250 (304)
Functional and Phenotypic Characterization of Siglec-6 on Human Mast Cells
Cells, 2022 Mast cells are tissue-resident cells that contribute to allergic diseases, among others, due to excessive or inappropriate cellular activation and degranulation. Therapeutic approaches to modulate mast cell activation are urgently needed.
Piper A. Robida +15 more
doaj +1 more source
Mast Cells as a Target—A Comprehensive Review of Recent Therapeutic Approaches
Cells, 2023 Mast cells (MCs) are the immune cells distributed throughout nearly all tissues, mainly in the skin, near blood vessels and lymph vessels, nerves, lungs, and the intestines.
Joanna Baran +7 more
doaj +1 more source
Advanced Science, EarlyView.A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu +6 more
wiley +1 more source
Frontiers in Immunology, 2023 Neutrophils are a specialized subset of white blood cells, which have the ability to store pre-formed mediators in their cytoplasmic granules. Neutrophils are well-known effector cells involved in host protection against pathogens through diverse ...
Lea Gigon +8 more
doaj +1 more source
Mast cell degranulation breaks peripheral tolerance [PDF]
, 2009 Mast cells (MC) have been shown to mediate regulatory T-cell (T(reg))-dependent, peripheral allograft tolerance in both skin and cardiac transplants. Furthermore, T(reg) have been implicated in mitigating IgE-mediated MC degranulation, establishing a ...
De Vries, V. C. +6 more
core +1 more source
Advanced Science, EarlyView.A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang +8 more
wiley +1 more source
Fungus-induced inflammation and eosinophil degranulation
, 2010 This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal polypeptides, methods for assessing fungus-induced inflammation,
core +1 more source
Frontiers in Pharmacology, 2021 Neutrophils are crucial elements of innate immune system, which assure host defense via a range of effector functions, such as phagocytosis, degranulation, and NET formation.
Barbara Gierlikowska +4 more
doaj +1 more source
Advanced Science, EarlyView.Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana +19 more
wiley +1 more source
Yersinia pseudotuberculosis Blocks Neutrophil Degranulation
, 2016 Neutrophils are essential components of immunity and are rapidly recruited to infected or injured tissue. Upon their activation, neutrophils release granules to the cell's exterior, through a process called degranulation.
Taheri, Nayyer, +5 more
core +1 more source