Results 31 to 40 of about 87,250 (304)
SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts
Biomedicines, 2022 SARS-CoV-2, the virus that causes COVID-19, has given rise to one of the largest pandemics, affecting millions worldwide. High neutrophil-to-lymphocyte ratios have been identified as an important correlate to poor recovery rates in severe COVID-19 ...
Abenaya Muralidharan +2 more
doaj +1 more source
Cells, 2021 The identification of the Mas-related G-protein-coupled receptors (Mrgpr) as targets of diverse stimuli of mast cells (MCs), including neuropeptides and pseudo-allergy causing drugs, has placed these receptors at a prime position in MC research. However,
Pia Lazki-Hagenbach +2 more
doaj +1 more source
Studies on the degranulation test for carcinogens [PDF]
FEBS Letters, 1983 The radiometric assay of degranulation of the hepatic endoplasmic reticulum by chemical carcinogens has been re‐examined. Both 1,2,3,4,‐ and 1,25,6‐dibenzanthracenes caused degranulation of rough membranes in vitro; with acetamidofluorenes and naphthylamines the carcinogenic analogues caused moderately greater degranulation.
Poole, Thomas W., Parke, Dennis V.
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2018 Degranulation refers to the secretion of inflammatory mediators, such as histamine, serotonin, and proteases, that are stored within the granules of mast cells and that trigger allergic reactions.
Satoru Yokawa +5 more
doaj +1 more source
Transcription Factors in the Development and Pro-Allergic Function of Mast Cells
Frontiers in Allergy, 2021 Mast cells (MCs) are innate immune cells of hematopoietic origin localized in the mucosal tissues of the body and are broadly implicated in the pathogenesis of allergic inflammation.
Mansi Srivastava, Mark H. Kaplan
doaj +1 more source
Inhibiting Degranulation in Immune Cell Signaling Pathways [PDF]
, 2020 Allergies are a pervasive issue and require novel ways of alleviating symptoms. Existing treatments are focused on symptom management and immunotherapy, but there is also potential to target the molecules involved in the downstream pathway, particularly ...
Fadul, Naja +10 more
core +1 more source
Calcineurin Aα Contributes to IgE-Dependent Mast-Cell Mediator Secretion in Allergic Inflammation
Journal of Innate Immunity, 2021 Mast cells (MCs) are key mediators of allergic inflammation through the activation of cross-linked immunoglobulin E (IgE) bound to the high-affinity IgE receptor (FcϵRI) on the cell surface, leading to the release of biologically potent mediators, either
Edwin Leong +3 more
doaj +1 more source
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
Stimulation of TRPV1 by green laser light [PDF]
, 2012 Low-level laser irradiation of visible light had been introduced as a medical treatment already more than 40 years ago, but its medical application still remains controversial.
Wang, Lina +3 more
core +1 more source
Proximity of micro-fissures and MC degranulation in human AAAs.
, 2023 Proximity of micro-fissures and MC degranulation in human AAAs.
Marion Morvan (528435) +22 more
core +1 more source